Higher prevalence of unrecognized kidney disease at high altitude

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dc.check.date2018-11-08
dc.check.infoAccess to this article is restricted until 12 months after publication by request of the publisher.en
dc.contributor.authorHurtado-Arestegui, Abdias
dc.contributor.authorPlata-Cornejo, Raul
dc.contributor.authorCornejo, Arturo
dc.contributor.authorMas, Guiliana
dc.contributor.authorCarbajal, Luz
dc.contributor.authorSharma, Shailendra
dc.contributor.authorSwenson, Erik R.
dc.contributor.authorJohnson, Richard J.
dc.contributor.authorPando, Jackelina
dc.contributor.funderInternational Society of Nephrologyen
dc.date.accessioned2018-01-10T09:53:52Z
dc.date.available2018-01-10T09:53:52Z
dc.date.issued2017-11-08
dc.date.updated2018-01-10T09:37:44Z
dc.description.abstractBackground: High altitude renal syndrome has been described in populations with excessive erythrocytosis. We evaluated whether high altitude (HA) dwellers might be at increased risk for kidney disease. Methods: We performed a cross-sectional study to investigate differences in prevalence of kidney function and metabolic syndrome in healthy subjects living at HA vs. sea level (SL) without any known history of hypertension, diabetes or chronic kidney disease. Results: We examined 293 subjects, aged 40 to 60 years: 125 SL (154 m) and 168 HA (3640 m) dwellers. HA dwellers had higher serum creatinine, lower estimated glomerular function rate (eGFR) (69.5 ± 15.2 vs. 102.1 ± 17.8 ml/min/1.73 m2, p < 0.0001), more proteinuria and higher hemoglobin concentrations compared to SL subjects. HA subjects had a lower prevalence of metabolic syndrome. Hemoglobin concentrations correlated inversely with eGFR in female (p = 0.001) and male (p = 0.03) HA dwellers. Using logistic regression analysis to compare subjects with eGFR < 90 vs. > 90 ml/min/1.73 m2, a lower eGFR was associated with female gender (odds ratio adjusted: 5.65 [95% confidence interval: 2.43–13.13]; p = 0.001), high altitude (14.78 [6.46–33.79]; p = 0.001), hemoglobin (1.68 [1.16–2.43]; p = 0.001) and uric acid (1.93 [1.36–2.72]; p = 0.001). Conclusions: Dwellers at high altitude who are considered healthy have worse kidney function, a higher prevalence of proteinuria and a lower prevalence of metabolic syndrome compared to people living at SL.en
dc.description.sponsorshipInternational Society of Nephrology (Global Outreach Research and Prevention Committee - Grant no. 03-018)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationHurtado-Arestegui, A., Plata-Cornejo, R., Cornejo, A., Mas, G., Carbajal, L., Sharma, S., Swenson, E. R., Johnson, R. J. and Pando, J. (2017) 'Higher prevalence of unrecognized kidney disease at high altitude', Journal of Nephrology, 31, pp. 263-269. doi:10.1007/s40620-017-0456-0en
dc.identifier.doi10.1007/s40620-017-0456-0
dc.identifier.endpage269
dc.identifier.issn1724-6059
dc.identifier.journaltitleJournal of Nephrologyen
dc.identifier.startpage263
dc.identifier.urihttps://hdl.handle.net/10468/5257
dc.identifier.volume31
dc.language.isoenen
dc.publisherSpringer International Publishing AG on behalf of the Italian Society of Nephrologyen
dc.rights© 2017, Italian Society of Nephrology. Published by Springer International Publishing AG. This is a post-peer-review, pre-copyedit version of an article published in Journal of Nephrology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s40620-017-0456-0en
dc.subjectCardiovascular risken
dc.subjectHigh altitudeen
dc.subjectKidney functionen
dc.subjectProteinuriaen
dc.titleHigher prevalence of unrecognized kidney disease at high altitudeen
dc.typeArticle (peer-reviewed)en
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