The impact of storage conditions upon gentamicin coated antimicrobial implants

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dc.contributor.authorMullins, Nicholas D.
dc.contributor.authorDeadman, Benjamin J.
dc.contributor.authorMoynihan, Humphrey A.
dc.contributor.authorMcCarthy, Florence O.
dc.contributor.authorLawrence, Simon E.
dc.contributor.authorThompson, Jonathan
dc.contributor.authorMaguire, Anita R.
dc.contributor.funderEnterprise Irelanden
dc.date.accessioned2016-12-14T10:33:26Z
dc.date.available2016-12-14T10:33:26Z
dc.date.issued2016-05-26
dc.date.updated2016-12-13T11:43:35Z
dc.description.abstractA systematic approach was developed to investigate the stability of gentamicin sulfate (GS) and GS/poly (lactic-co-glycolic acid) (PLGA) coatings on hydroxyapatite surfaces. The influence of environmental factors (light, humidity, oxidation and heat) upon degradation of the drug in the coatings was investigated using liquid chromatography with evaporative light scattering detection and mass spectrometry. GS coated rods were found to be stable across the range of environments assessed, with only an oxidizing atmosphere resulting in significant changes to the gentamicin composition. In contrast, rods coated with GS/PLGA were more sensitive to storage conditions with compositional changes being detected after storage at 60 °C, 75% relative humidity or exposure to light. The effect of γ-irradiation on the coated rods was also investigated and found to have no significant effect. Finally, liquid chromatography–mass spectrometry analysis revealed that known gentamines C1, C1a and C2 were the major degradants formed. Forced degradation of gentamicin coatings did not produce any unexpected degradants or impurities.en
dc.description.sponsorshipDePuy Synthes (Ireland); Enterprise Ireland (IP 2010-0068)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMullins, N. D., Deadman, B. J., Moynihan, H. A., McCarthy, F. O., Lawrence, S. E., Thompson, J. and Maguire, A. R. (2016) 'The impact of storage conditions upon gentamicin coated antimicrobial implants', Journal of Pharmaceutical Analysis, 6(6), pp. 374-381. doi:10.1016/j.jpha.2016.05.002en
dc.identifier.doi10.1016/j.jpha.2016.05.002
dc.identifier.endpage381en
dc.identifier.issn2095-1779
dc.identifier.issued6en
dc.identifier.journaltitleJournal of Pharmaceutical and Biomedical Analysisen
dc.identifier.startpage374en
dc.identifier.urihttps://hdl.handle.net/10468/3378
dc.identifier.volume6en
dc.language.isoenen
dc.publisherElsevieren
dc.rights© 2016 Xi'an Jiaotong University. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND licenseen
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectGentamicinen
dc.subjectStorage stability testingen
dc.subjectLC–ELSDen
dc.subjectCoatingsen
dc.titleThe impact of storage conditions upon gentamicin coated antimicrobial implantsen
dc.typeArticle (peer-reviewed)en
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