The first microbial colonizers of the human gut: composition, activities, and health implications of the infant gut microbiota

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dc.contributor.authorMilani, Christian
dc.contributor.authorDuranti, Sabrina
dc.contributor.authorBottacini, Francesca
dc.contributor.authorCasey, Eoghan
dc.contributor.authorTurroni, Francesca
dc.contributor.authorMahony, Jennifer
dc.contributor.authorBelzer, Clara
dc.contributor.authorDelgado Palacio, Susana
dc.contributor.authorArboleya, Silvia
dc.contributor.authorMancabelli, Leonardo
dc.contributor.authorLugli, Gabriele A.
dc.contributor.authorMiguel Rodriguez, Juan
dc.contributor.authorBode, Lars
dc.contributor.authorde Vos, Willem M.
dc.contributor.authorGueimonde, Miguel
dc.contributor.authorMargolles, Abelardo
dc.contributor.authorvan Sinderen, Douwe
dc.contributor.authorVentura, Marco
dc.contributor.funderScience Foundation Ireland
dc.contributor.funderInstituto Danone
dc.contributor.funderMinisterio de Economía y Competitividad
dc.contributor.funderMinistero dell’Istruzione, dell’Università e della Ricerca
dc.contributor.funderJoint Programming Initiative A healthy diet for a healthy life
dc.date.accessioned2018-09-24T12:36:59Z
dc.date.available2018-09-24T12:36:59Z
dc.date.issued2017
dc.description.abstractThe human gut microbiota is engaged in multiple interactions affecting host health during the host's entire life span. Microbes colonize the neonatal gut immediately following birth. The establishment and interactive development of this early gut microbiota are believed to be (at least partially) driven and modulated by specific compounds present in human milk. It has been shown that certain genomes of infant gut commensals, in particular those of bifidobacterial species, are genetically adapted to utilize specific glycans of this human secretory fluid, thus representing a very intriguing example of host-microbe coevolution, where both partners are believed to benefit. In recent years, various metagenomic studies have tried to dissect the composition and functionality of the infant gut microbiome and to explore the distribution across the different ecological niches of the infant gut biogeography of the corresponding microbial consortia, including those corresponding to bacteria and viruses, in healthy and ill subjects. Such analyses have linked certain features of the microbiota/microbiome, such as reduced diversity or aberrant composition, to intestinal illnesses in infants or disease states that are manifested at later stages of life, including asthma, inflammatory bowel disease, and metabolic disorders. Thus, a growing number of studies have reported on how the early human gut microbiota composition/development may affect risk factors related to adult health conditions. This concept has fueled the development of strategies to shape the infant microbiota composition based on various functional food products. In this review, we describe the infant microbiota, the mechanisms that drive its establishment and composition, and how microbial consortia may be molded by natural or artificial interventions. Finally, we discuss the relevance of key microbial players of the infant gut microbiota, in particular bifidobacteria, with respect to their role in health and disease.en
dc.description.sponsorshipMinisterio de Economía y Competitividad (PCIN-2015-233; AGL2016-75476-R); Instituto Danone/Ministerio de Economía y Competitividad (Spanish Plan Estatal de I+D+I (reference AGL2016-78311-R)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleide00036-17
dc.identifier.citationMilani, C., Duranti, S., Bottacini, F., Casey, E., Turroni, F., Mahony, J., Belzer, C., Delgado Palacio, S., Arboleya Montes, S., Mancabelli, L., Lugli, G. A., Rodriguez, J. M., Bode, L., de Vos, W., Gueimonde, M., Margolles, A., van Sinderen, D. and Ventura, M. (2017) 'The first microbial colonizers of the human gut: composition, activities, and health implications of the infant gut microbiota', Microbiology and Molecular Biology Reviews, 81(4), e00036-17 (67pp). doi: 10.1128/MMBR.00036-17en
dc.identifier.doi10.1128/MMBR.00036-17
dc.identifier.endpage67
dc.identifier.issn1092-2172
dc.identifier.issued4
dc.identifier.journaltitleMicrobiology and Molecular Biology Reviewsen
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/10468/6878
dc.identifier.volume81
dc.language.isoenen
dc.publisherAmerican Society for Microbiologyen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Starting Investigator Research Grant (SIRG)/15/SIRG/3430/IE/Phage-host interactome of the dairy bacterium Streptococcus thermophilus (PHIST)/
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/
dc.relation.urihttps://mmbr.asm.org/content/81/4/e00036-17
dc.rights© 2017, American Society for Microbiology. All rights reserved.en
dc.subjectMicrobiomeen
dc.subjectMicrobiotaen
dc.subjectInfantsen
dc.subjectMetagenomicsen
dc.subjectViromeen
dc.subjectBifidobacteriaen
dc.subjectGut commensalsen
dc.subjectProbioticsen
dc.subjectGut microbiotaen
dc.titleThe first microbial colonizers of the human gut: composition, activities, and health implications of the infant gut microbiotaen
dc.typeReviewen
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