dc.contributor.author	Ivanov, Ivaylo P.
dc.contributor.author	Atkins, John F.
dc.contributor.funder	Science Foundation Ireland
dc.date.accessioned	2017-11-14T13:24:32Z
dc.date.available	2017-11-14T13:24:32Z
dc.date.issued	2007
dc.description.abstract	The protein antizyme is a negative regulator of intracellular polyamine levels. Ribosomes synthesizing antizyme start in one ORF and at the codon 5' adjacent to its stop codon, shift +1 to a second and partially overlapping ORF which encodes most of the protein. The ribosomal frameshifting is a sensor and effector of an autoregulatory circuit which is conserved in animals, fungi and protists. Stimulatory signals encoded 5' and 3' of the shift site act to program the frameshifting. Despite overall conservation, many individual branches have evolved specific features surrounding the frameshift site. Among these are RNA pseudoknots, RNA stem-loops, conserved primary RNA sequences, nascent peptide sequences and branch-specific 'shifty' codons.	en
dc.description.status	Peer reviewed	en
dc.description.version	Published Version	en
dc.format.mimetype	application/pdf	en
dc.identifier.citation	Ivanov, I. P. and Atkins, J. F. (2007) 'Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation', Nucleic Acids Research, 35(6), pp. 1842-1858. doi: 10.1093/nar/gkm035	en
dc.identifier.doi	10.1093/nar/gkm035
dc.identifier.endpage	1858
dc.identifier.issn	0305-1048
dc.identifier.issued	6
dc.identifier.journaltitle	Nucleic Acids Research	en
dc.identifier.startpage	1842
dc.identifier.uri	https://hdl.handle.net/10468/5033
dc.identifier.volume	35
dc.language.iso	en	en
dc.publisher	Oxford University Press	en
dc.relation.uri	https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/gkm035
dc.rights	© 2007, the Authors. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/2.0/uk/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.	en
dc.rights.uri	https://creativecommons.org/licenses/by-nc/2.0/uk/
dc.subject	Ornithine-decarboxylase antizyme	en
dc.subject	Zebrafish danio-rerio	en
dc.subject	Escherichia-coli	en
dc.subject	Cell growth	en
dc.subject	Polyamine transport	en
dc.subject	Mammalian antizyme	en
dc.subject	Regulatory protein	en
dc.subject	Release factor-2	en
dc.subject	Drosophila gene	en
dc.subject	Fission yeast	en
dc.title	Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation	en
dc.type	Article (peer-reviewed)	en

Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation

Files

Original bundle

Collections