Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation

dc.contributor.authorIvanov, Ivaylo P.
dc.contributor.authorAtkins, John F.
dc.contributor.funderScience Foundation Ireland
dc.date.accessioned2017-11-14T13:24:32Z
dc.date.available2017-11-14T13:24:32Z
dc.date.issued2007
dc.description.abstractThe protein antizyme is a negative regulator of intracellular polyamine levels. Ribosomes synthesizing antizyme start in one ORF and at the codon 5' adjacent to its stop codon, shift +1 to a second and partially overlapping ORF which encodes most of the protein. The ribosomal frameshifting is a sensor and effector of an autoregulatory circuit which is conserved in animals, fungi and protists. Stimulatory signals encoded 5' and 3' of the shift site act to program the frameshifting. Despite overall conservation, many individual branches have evolved specific features surrounding the frameshift site. Among these are RNA pseudoknots, RNA stem-loops, conserved primary RNA sequences, nascent peptide sequences and branch-specific 'shifty' codons.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationIvanov, I. P. and Atkins, J. F. (2007) 'Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation', Nucleic Acids Research, 35(6), pp. 1842-1858. doi: 10.1093/nar/gkm035en
dc.identifier.doi10.1093/nar/gkm035
dc.identifier.endpage1858
dc.identifier.issn0305-1048
dc.identifier.issued6
dc.identifier.journaltitleNucleic Acids Researchen
dc.identifier.startpage1842
dc.identifier.urihttps://hdl.handle.net/10468/5033
dc.identifier.volume35
dc.language.isoenen
dc.publisherOxford University Pressen
dc.relation.urihttps://academic.oup.com/nar/article-lookup/doi/10.1093/nar/gkm035
dc.rights© 2007, the Authors. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/2.0/uk/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc/2.0/uk/
dc.subjectOrnithine-decarboxylase antizymeen
dc.subjectZebrafish danio-rerioen
dc.subjectEscherichia-colien
dc.subjectCell growthen
dc.subjectPolyamine transporten
dc.subjectMammalian antizymeen
dc.subjectRegulatory proteinen
dc.subjectRelease factor-2en
dc.subjectDrosophila geneen
dc.subjectFission yeasten
dc.titleRibosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservationen
dc.typeArticle (peer-reviewed)en
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