Age-dependent differences in pulmonary host responses in ARDS: A prospective observational cohort study

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dc.contributor.authorSchouten, Laura R.
dc.contributor.authorvan Kaam, Anton H.
dc.contributor.authorKohse, Franziska
dc.contributor.authorVeltkamp, Floor
dc.contributor.authorBos, Lieuwe D.
dc.contributor.authorde Beer, Friso M.
dc.contributor.authorvan Hooijdonk, Roosmarijn T.
dc.contributor.authorHorn, Janneke
dc.contributor.authorStraat, Marleen
dc.contributor.authorWitteveen, Esther
dc.contributor.authorGlas, Gerie J.
dc.contributor.authorWieske, Luuk
dc.contributor.authorvan Vught, Lonneke A.
dc.contributor.authorWiewel, Maryse A.
dc.contributor.authorIngelse, Sarah A.
dc.contributor.authorCortjens, Bart
dc.contributor.authorvan Woensel, Job B.
dc.contributor.authorBos, Albert P.
dc.contributor.authorWalther, Thomas
dc.contributor.authorSchultz, Marcus J.
dc.contributor.authorWösten-van Asperen, Roelie M.
dc.contributor.funderCenter for Translational Molecular Medicineen
dc.date.accessioned2019-11-20T05:21:18Z
dc.date.available2019-11-20T05:21:18Z
dc.date.issued2019-05-14
dc.description.abstractBackground: Results from preclinical studies suggest that age-dependent differences in host defense and the pulmonary renin–angiotensin system (RAS) are responsible for observed differences in epidemiology of acute respiratory distress syndrome (ARDS) between children and adults. The present study compares biomarkers of host defense and RAS in bronchoalveolar lavage (BAL) fluid from neonates, children, adults, and older adults with ARDS. Methods: In this prospective observational study, we enrolled mechanical ventilated ARDS patients categorized into four age groups: 20 neonates (< 28 days corrected postnatal age), 29 children (28 days–18 years), 26 adults (18–65 years), and 17 older adults (> 65 years of age). All patients underwent a nondirected BAL within 72 h after intubation. Activities of the two main enzymes of RAS, angiotensin converting enzyme (ACE) and ACE2, and levels of biomarkers of inflammation, endothelial activation, and epithelial damage were determined in BAL fluid. Results: Levels of myeloperoxidase, interleukin (IL)-6, IL-10, and p-selectin were higher with increasing age, whereas intercellular adhesion molecule-1 was higher in neonates. No differences in activity of ACE and ACE2 were seen between the four age groups. Conclusions: Age-dependent differences in the levels of biomarkers in lungs of ARDS patients are present. Especially, higher levels of markers involved in the neutrophil response were found with increasing age. In contrast to preclinical studies, age is not associated with changes in the pulmonary RAS.en
dc.description.sponsorship041-201en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid55en
dc.identifier.citationSchouten, L.R., van Kaam, A.H., Kohse, F., Veltkamp, F., Bos, L.D., de Beer, F.M., van Hooijdonk, R.T., Horn, J., Straat, M., Witteveen, E. and Glas, G.J., 2019. Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study. Annals of intensive care, 9(1), (55). DOI:10.1186/s13613-019-0529-4en
dc.identifier.doi10.1186/s13613-019-0529-4en
dc.identifier.eissn2110-5820
dc.identifier.endpage9en
dc.identifier.issued1en
dc.identifier.journaltitleAnnals of Intensive Careen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/9115
dc.identifier.volume9en
dc.language.isoenen
dc.publisherSpringer Openen
dc.relation.projectMolecular Diagnosis and Risk stratification of Sepsis (MARS)en
dc.relation.urihttps://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-019-0529-4
dc.rights© The Author(s) 2019en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectARDSen
dc.subjectAngiotensin converting enzymeen
dc.subjectPathophysiologyen
dc.subjectAgingen
dc.subjectHost responseen
dc.subjectBiomarkersen
dc.titleAge-dependent differences in pulmonary host responses in ARDS: A prospective observational cohort studyen
dc.typeArticle (peer-reviewed)en
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