Protecting the outside: biological tools to manipulate the skin microbiota

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dc.contributor.authorO'Sullivan, Julie N.
dc.contributor.authorRea, Mary C.
dc.contributor.authorHill, Colin
dc.contributor.authorRoss, R. Paul
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2021-10-07T12:03:43Z
dc.date.available2021-10-07T12:03:43Z
dc.date.issued2020-05-12
dc.date.updated2021-10-07T11:45:43Z
dc.description.abstractInterest surrounding the role that skin microbes play in various aspects of human health has recently experienced a timely surge, particularly among researchers, clinicians and consumer-focused industries. The world is now approaching a post-antibiotic era where conventional antibacterial therapeutics have shown a loss in effectiveness due to overuse, leading to the looming antibiotic resistance crisis. The increasing threat posed by antibiotic resistance is compounded by an inadequate discovery rate of new antibiotics and has, in turn, resulted in global interest for alternative solutions. Recent studies have demonstrated that imbalances in skin microbiota are associated with assorted skin diseases and infections. Specifically, restoration of this ecosystem imbalance results in an alleviation of symptoms, achieved simply by applying bacteria normally found in abundance on healthy skin to the skin of those deficient in beneficial bacteria. The aim of this review is to discuss the currently available literature on biological tools that have the potential to manipulate the skin microbiota, with particular focus on bacteriocins, phage therapy, antibiotics, probiotics and targets of the gut-skin axis. This review will also address how the skin microbiota protects humans from invading pathogens in the external environment while discussing novel strategies to manipulate the skin microbiota to avoid and/or treat various disease states.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleidfiaa085en
dc.identifier.citationO'Sullivan, J. N., Rea, M. C., Hill, C. and Ross, R. P. (2020) 'Protecting the outside: biological tools to manipulate the skin microbiota', FEMS Microbiology Ecology, 96(6), fiaa085 (14pp). doi: 10.1093/femsec/fiaa085en
dc.identifier.doi10.1093/femsec/fiaa085en
dc.identifier.eissn1574-6941
dc.identifier.endpage14en
dc.identifier.issn0168-6496
dc.identifier.issued6en
dc.identifier.journaltitleFEMS Microbiology Ecologyen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/12061
dc.identifier.volume96en
dc.language.isoenen
dc.publisherOxford University Pressen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.rights© 2020, FEMS. All rights reserved. This is a pre-copyedited, author-produced version of an article accepted for publication in FEMS Microbiology Ecology following peer review. The version of record [O'Sullivan, J. N., Rea, M. C., Hill, C. and Ross, R. P. (2020) 'Protecting the outside: biological tools to manipulate the skin microbiota', FEMS Microbiology Ecology, 96(6), fiaa085 (14pp). doi: 10.1093/femsec/fiaa085] is available online at: https://doi.org/10.1093/femsec/fiaa085en
dc.subjectBacteriocinen
dc.subjectGut-skin axisen
dc.subjectPhageen
dc.subjectProbioticsen
dc.subjectSkin microbiotaen
dc.titleProtecting the outside: biological tools to manipulate the skin microbiotaen
dc.typeArticle (peer-reviewed)en
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