Comparative genomics analysis of Lactobacillus mucosae from different niches

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dc.contributor.authorJia, Yan
dc.contributor.authorYang, Bo
dc.contributor.authorRoss, R. Paul
dc.contributor.authorStanton, Catherine
dc.contributor.authorZhang, Hao
dc.contributor.authorJianxin
dc.contributor.authorChen, Wei
dc.contributor.funderNational Natural Science Foundation of Chinaen
dc.contributor.funderNational First-Class Discipline Program of Food Science and Technologyen
dc.contributor.funderCollaborative Innovationcenter of Food Safety and Quality Control in Jiangsu Provinceen
dc.date.accessioned2023-03-03T15:04:41Z
dc.date.available2023-03-03T15:04:41Z
dc.date.issued2020-01
dc.date.updated2023-03-03T14:45:02Z
dc.description.abstractThe potential probiotic benefits of Lactobacillus mucosae have received increasing attention. To investigate the genetic diversity of L. mucosae, comparative genomic analyses of 93 strains isolated from different niches (human and animal gut, human vagina, etc.) and eight strains of published genomes were conducted. The results showed that the core genome of L. mucosae mainly encoded translation and transcription, amino acid biosynthesis, sugar metabolism, and defense function while the pan-genomic curve tended to be close. The genetic diversity of L. mucosae mainly reflected in carbohydrate metabolism and immune/competitive-related factors, such as exopolysaccharide (EPS), enterolysin A, and clustered regularly interspaced short palindromic repeats (CRISPR)-Cas. It was worth noting that this research firstly predicted the complete EPS operon shared among L. mucosae. Additionally, the type IIIA CRISPR-Cas system was discovered in L. mucosae for the first time. This work provided new ideas for the study of this species.en
dc.description.sponsorshipNational Natural Science Foundation of China (Nos. 31771953, 31820103010); National First-Class Discipline Program of Food Science and Technology (JUFSTR20180102)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid95en
dc.identifier.citationJia, Y., Yang, B., Ross, R. P., Stanton, C., Zhang, H., Zhao, J. and Chen, W. (2020) ‘Comparative genomics analysis of lactobacillus mucosae from different niches’, Genes, 11(1), 95 (20pp). doi: 10.3390/genes11010095en
dc.identifier.doi10.3390/genes11010095en
dc.identifier.endpage20en
dc.identifier.issn2073-4425
dc.identifier.issued1en
dc.identifier.journaltitleGenesen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/14277
dc.identifier.volume11en
dc.language.isoenen
dc.publisherMDPIen
dc.rights© 2020, by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectCarbohydrateen
dc.subjectComparative genomicsen
dc.subjectCRISPR-Casen
dc.subjectEnterolysin Aen
dc.subjectEPSen
dc.subjectLactobacillus mucosaeen
dc.titleComparative genomics analysis of Lactobacillus mucosae from different nichesen
dc.typeArticle (peer-reviewed)en
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