Comparative genomics analysis of Lactobacillus mucosae from different niches
dc.contributor.author | Jia, Yan | |
dc.contributor.author | Yang, Bo | |
dc.contributor.author | Ross, R. Paul | |
dc.contributor.author | Stanton, Catherine | |
dc.contributor.author | Zhang, Hao | |
dc.contributor.author | Jianxin | |
dc.contributor.author | Chen, Wei | |
dc.contributor.funder | National Natural Science Foundation of China | en |
dc.contributor.funder | National First-Class Discipline Program of Food Science and Technology | en |
dc.contributor.funder | Collaborative Innovationcenter of Food Safety and Quality Control in Jiangsu Province | en |
dc.date.accessioned | 2023-03-03T15:04:41Z | |
dc.date.available | 2023-03-03T15:04:41Z | |
dc.date.issued | 2020-01 | |
dc.date.updated | 2023-03-03T14:45:02Z | |
dc.description.abstract | The potential probiotic benefits of Lactobacillus mucosae have received increasing attention. To investigate the genetic diversity of L. mucosae, comparative genomic analyses of 93 strains isolated from different niches (human and animal gut, human vagina, etc.) and eight strains of published genomes were conducted. The results showed that the core genome of L. mucosae mainly encoded translation and transcription, amino acid biosynthesis, sugar metabolism, and defense function while the pan-genomic curve tended to be close. The genetic diversity of L. mucosae mainly reflected in carbohydrate metabolism and immune/competitive-related factors, such as exopolysaccharide (EPS), enterolysin A, and clustered regularly interspaced short palindromic repeats (CRISPR)-Cas. It was worth noting that this research firstly predicted the complete EPS operon shared among L. mucosae. Additionally, the type IIIA CRISPR-Cas system was discovered in L. mucosae for the first time. This work provided new ideas for the study of this species. | en |
dc.description.sponsorship | National Natural Science Foundation of China (Nos. 31771953, 31820103010); National First-Class Discipline Program of Food Science and Technology (JUFSTR20180102) | en |
dc.description.status | Peer reviewed | en |
dc.description.version | Published Version | en |
dc.format.mimetype | application/pdf | en |
dc.identifier.articleid | 95 | en |
dc.identifier.citation | Jia, Y., Yang, B., Ross, R. P., Stanton, C., Zhang, H., Zhao, J. and Chen, W. (2020) ‘Comparative genomics analysis of lactobacillus mucosae from different niches’, Genes, 11(1), 95 (20pp). doi: 10.3390/genes11010095 | en |
dc.identifier.doi | 10.3390/genes11010095 | en |
dc.identifier.endpage | 20 | en |
dc.identifier.issn | 2073-4425 | |
dc.identifier.issued | 1 | en |
dc.identifier.journaltitle | Genes | en |
dc.identifier.startpage | 1 | en |
dc.identifier.uri | https://hdl.handle.net/10468/14277 | |
dc.identifier.volume | 11 | en |
dc.language.iso | en | en |
dc.publisher | MDPI | en |
dc.rights | © 2020, by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ | en |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en |
dc.subject | Carbohydrate | en |
dc.subject | Comparative genomics | en |
dc.subject | CRISPR-Cas | en |
dc.subject | Enterolysin A | en |
dc.subject | EPS | en |
dc.subject | Lactobacillus mucosae | en |
dc.title | Comparative genomics analysis of Lactobacillus mucosae from different niches | en |
dc.type | Article (peer-reviewed) | en |