Biosensing in dermal interstitial fluid using microneedle based electrochemical devices

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dc.contributor.authorMadden, Julia
dc.contributor.authorO'Mahony, Conor
dc.contributor.authorThompson, Michael
dc.contributor.authorO'Riordan, Alan
dc.contributor.authorGalvin, Paul
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2021-02-23T13:11:38Z
dc.date.available2021-02-23T13:11:38Z
dc.date.issued2020-05-15
dc.date.updated2021-02-23T13:01:15Z
dc.description.abstractThis article explores recent advances in the development of electrochemical biosensors on microneedle platforms towards on-device sensing of biomarkers present in dermal interstitial fluid. The integration of a biosensor with a microneedle platform opens the possibility for minimally invasive bio-chemical detection or continuous monitoring within the dermal interstitial fluid. An introduction to interstitial fluid is provided placing emphasis on sampling methods that have been employed to extract and/or sample tissue fluid for analysis. We look briefly at microneedle technologies used to extract dermal interstitial fluid for subsequent analysis. Successive content will focus on microneedle technologies which have been integrated with electrochemical biosensors for the quantification of various metabolites, electrolytes and other miscellaneous entities known to be present in the dermal interstitial fluid. The review concludes with some of the key challenges and opportunities faced by this next-generation wearable sensing technology.en
dc.description.sponsorshipScience Foundation Ireland (SFI through the Insight Centre for Data Analytics Initiative, grant numbers SFI/12/RC/2289 and SFI/12/RC/2289-P2)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid100348en
dc.identifier.citationMadden, J., O'Mahony, C., Thompson, M., O'Riordan, A. and Galvin, P. (2020) 'Biosensing in dermal interstitial fluid using microneedle based electrochemical devices', Sensing and Bio-Sensing Research, 29, 100348 (17 pp). doi: 10.1016/j.sbsr.2020.100348en
dc.identifier.doi10.1016/j.sbsr.2020.100348en
dc.identifier.endpage17en
dc.identifier.issn2214-1804
dc.identifier.journaltitleSensing and Bio-Sensing Researchen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/11096
dc.identifier.volume29en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2289/IE/INSIGHT - Irelands Big Data and Analytics Research Centre/en
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S2214180420300064
dc.rights© 2020 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/)en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectBiosensoren
dc.subjectDermal interstitial fluiden
dc.subjectElectrochemicalen
dc.subjectMicroneedleen
dc.titleBiosensing in dermal interstitial fluid using microneedle based electrochemical devicesen
dc.typeArticle (peer-reviewed)en
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