Determination optical properties of tissue-like phantoms using diffuse reflectance and transmittance spectroscopy

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Lu, Huihui
Gunther, Jacqueline
Andersson-Engels, Stefan
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Society of Photo-optical Instrumentation Engineers (SPIE)
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We present a simple, convenient fibre-optics probe system for the determination optical properties of tissue-like liquid phantoms based on diffuse reflectance and transmittance measurements at the wavelength of visible-near-infrared region. The method combined Monte Carlo simulations, multiple polynomial regression and a Newton-Raphson algorithm for solving nonlinear equation system. In the range of optical properties of phantom with the μa at 0 – 0.5 cm-1 and the μs’ at 3 – 45 cm-1, the mean prediction error at 630 nm was 1.91 % for μs’ and 7.51 % for μa. The performance of the method is further tested by predictive error and validated using similar matrix of milk-ink phantoms on reflectance and transmittance.
Optical properties , Spectroscopy , Fibre-optics , Tissue diagnostics
Lu, H., Gunther, J. and Andersson-Engels, S. (2018) 'Determination optical properties of tissue-like phantoms using diffuse reflectance and transmittance spectroscopy', Proceedings of SPIE 10820: Optics in Health Care and Biomedical Optics VIII, 108202X (7pp), SPIE/COS Photonics Asia 2018, Beijing, China, 11-13 October. doi:10.1117/12.2501183
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