Encephalitis associated with autoantibodies binding to γ-aminobutyric acid-A, γ-aminobutyric acid-B and glycine receptors: immunopathogenic mechanisms and clinical characteristics

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dc.contributor.authorQuek, Amy May Lin
dc.contributor.authorO'Toole, Orna
dc.date.accessioned2018-09-06T10:39:35Z
dc.date.available2018-09-06T10:39:35Z
dc.date.issued2016
dc.description.abstractRecent, discoveries of neural antibodies have facilitated the diagnosis of immune-mediated, immunotherapy-responsive neurologic disorders. Antibodies that target inhibitory central nervous system receptors, such as γ-aminobutyric acid-B, γ-aminobutyric acid-A, and glycine receptors, disrupt inhibitory regulatory synaptic functions, and lead to neuronal hyperexcitability. The myriad of neurologic, manifestations associated with these antibodies includes seizures, encephalopathy, muscle rigidity and stiffness. This article provides a review of the immunopathogenic mechanisms and the clinical and therapeutic implications of autoimmune encephalitis associated with these antibodies that target inhibitory receptors.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationQuek, A. M. L. and O'Toole, O. (2016) 'Encephalitis associated with autoantibodies binding to γ-aminobutyric acid-A, γ-aminobutyric acid-B and glycine receptors: immunopathogenic mechanisms and clinical characteristics', Neuroimmunology and Neuroinflammation, 3, pp. 86-92. doi: 10.4103/2347-8659.170633en
dc.identifier.doi10.4103/2347-8659.170633
dc.identifier.endpage92
dc.identifier.issn2347-8659
dc.identifier.issn2349-6142
dc.identifier.journaltitleNeuroimmunology and Neuroinflammationen
dc.identifier.startpage86
dc.identifier.urihttps://hdl.handle.net/10468/6725
dc.identifier.volume3
dc.language.isoenen
dc.publisherOAE Publishing Inc.en
dc.relation.urihttp://nnjournal.net/article/view/1359/855
dc.rights© 2016, Neuroimmunology and Neuroinflammation. Published by OAE Publishing Inc. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License (http://creativecommons.org/licenses/by-nc-sa/3.0/), which allows others to remix, tweak and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/
dc.subjectAutoimmune encephalitisen
dc.subjectAutoimmune epilepsyen
dc.subjectLimbic encephalitisen
dc.subjectNeural antibodiesen
dc.titleEncephalitis associated with autoantibodies binding to γ-aminobutyric acid-A, γ-aminobutyric acid-B and glycine receptors: immunopathogenic mechanisms and clinical characteristicsen
dc.typeArticle (peer-reviewed)en
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