Encephalitis associated with autoantibodies binding to γ-aminobutyric acid-A, γ-aminobutyric acid-B and glycine receptors: immunopathogenic mechanisms and clinical characteristics
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Published Version
Date
2016
Authors
Quek, Amy May Lin
O'Toole, Orna
Journal Title
Journal ISSN
Volume Title
Publisher
OAE Publishing Inc.
Published Version
Abstract
Recent, discoveries of neural antibodies have facilitated the diagnosis of immune-mediated, immunotherapy-responsive neurologic disorders. Antibodies that target inhibitory central nervous system receptors, such as γ-aminobutyric acid-B, γ-aminobutyric acid-A, and glycine receptors, disrupt inhibitory regulatory synaptic functions, and lead to neuronal hyperexcitability. The myriad of neurologic, manifestations associated with these antibodies includes seizures, encephalopathy, muscle rigidity and stiffness. This article provides a review of the immunopathogenic mechanisms and the clinical and therapeutic implications of autoimmune encephalitis associated with these antibodies that target inhibitory receptors.
Description
Keywords
Autoimmune encephalitis , Autoimmune epilepsy , Limbic encephalitis , Neural antibodies
Citation
Quek, A. M. L. and O'Toole, O. (2016) 'Encephalitis associated with autoantibodies binding to γ-aminobutyric acid-A, γ-aminobutyric acid-B and glycine receptors: immunopathogenic mechanisms and clinical characteristics', Neuroimmunology and Neuroinflammation, 3, pp. 86-92. doi: 10.4103/2347-8659.170633