A tool to encourage minimum reporting guideline uptake for data analysis in metabolomics

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dc.contributor.authorConsidine, Elizabeth C.
dc.contributor.authorSalek, Reza M.
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2019-11-19T12:14:56Z
dc.date.available2019-11-19T12:14:56Z
dc.date.issued2019-03-05
dc.description.abstractDespite the proposal of minimum reporting guidelines for metabolomics over a decade ago, reporting on the data analysis step in metabolomics studies has been shown to be unclear and incomplete. Major omissions and a lack of logical flow render the data analysis’ sections in metabolomics studies impossible to follow, and therefore replicate or even imitate. Here, we propose possible reasons why the original reporting guidelines have had poor adherence and present an approach to improve their uptake. We present in this paper an R markdown reporting template file that guides the production of text and generates workflow diagrams based on user input. This R Markdown template contains, as an example in this instance, a set of minimum information requirements specifically for the data pre-treatment and data analysis section of biomarker discovery metabolomics studies, (gleaned directly from the original proposed guidelines by Goodacre at al). These minimum requirements are presented in the format of a questionnaire checklist in an R markdown template file. The R Markdown reporting template proposed here can be presented as a starting point to encourage the data analysis section of a metabolomics manuscript to have a more logical presentation and to contain enough information to be understandable and reusable. The idea is that these guidelines would be open to user feedback, modification and updating by the metabolomics community via GitHub.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid43en
dc.identifier.citationConsidine, E.C. and Salek, R.M., 2019. A Tool to Encourage Minimum Reporting Guideline Uptake for Data Analysis in Metabolomics. Metabolites, 9(3), (43). DOI:10.3390/metabo9030043en
dc.identifier.doi10.3390/metabo9030043en
dc.identifier.eissn2218-1989
dc.identifier.endpage11en
dc.identifier.issn2218-1989
dc.identifier.issued3en
dc.identifier.journaltitleMetabolitesen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/9097
dc.identifier.volume9en
dc.language.isoenen
dc.publisherMDPI AGen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2272/IE/Irish Centre for Fetal and Neonatal Translational Research (INFANT)/en
dc.relation.urihttps://www.mdpi.com/2218-1989/9/3/43
dc.rights© 2019 by the authors. Licensee MDPI, Basel, Switzerlanden
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectReproducibilityen
dc.subjectMinimum guidelinesen
dc.subjectReportingen
dc.subjectData analysisen
dc.titleA tool to encourage minimum reporting guideline uptake for data analysis in metabolomicsen
dc.typeArticle (peer-reviewed)en
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