Poles apart: where and how cells construct nisin

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dc.contributor.authorHill, Colinen
dc.date.accessioned2024-03-28T13:01:25Z
dc.date.available2024-03-28T13:01:25Z
dc.date.issued2020en
dc.description.abstractNisin is a 34-amino-acid lantibiotic that has been used commercially for almost a century as a food preservative. In order to produce active nisin, Lactococcus lactis requires an 11-gene operon that encodes proteins involved in modification, processing, transport, immunity, and regulation. While the role of each of the 11 proteins is well understood, the location and spatial organization of the biosynthetic machinery that involves NisA, NisB, NisC, NisT, and NisP remain to be determined. In this elegant paper (J. Chen, A. J. van Heel, and O. P. Kuipers, mBio 11:e02825-20, 2020, https://doi.org/10.1128/mBio.02825-20), we learn that a NisB dimer is recruited to the “old” pole of a dividing cell, where it assembles with NisC to form a modification complex that can engage with NisA. Unexpectedly, the NisT transporter does not stably assemble into this complex but is distributed around the membrane until it engages with the NisABC complex to transport NisA across the membrane, whereupon it dissociates from NisBC.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid02991-20en
dc.identifier.citationHill, C. (2020) ‘Poles apart: where and how cells construct nisin’, mBio, 11(6), e02991-20 (4pp). doi: 10.1128/mBio.02991-20en
dc.identifier.doi10.1128/mBio.02991-20en
dc.identifier.eissn2150-7511en
dc.identifier.endpage4en
dc.identifier.issn2161-2129en
dc.identifier.issued6en
dc.identifier.journaltitlemBioen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/15717
dc.identifier.volume11en
dc.language.isoenen
dc.publisherAmerican Society for Microbiologyen
dc.rights© 2020 Hill. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectBacteriocinsen
dc.subjectBiosynthesisen
dc.subjectNisinen
dc.titlePoles apart: where and how cells construct nisinen
dc.typeArticle (peer-reviewed)en
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