Cell wall polysaccharides of Gram positive ovococcoid bacteria and their role as bacteriophage receptors
| dc.contributor.author | Lavelle, Katherine | en |
| dc.contributor.author | van Sinderen, Douwe | en |
| dc.contributor.author | Mahony, Jennifer | en |
| dc.contributor.funder | Science Foundation Ireland | en |
| dc.date.accessioned | 2023-11-29T14:56:46Z | |
| dc.date.available | 2023-11-29T14:56:46Z | |
| dc.date.issued | 2021 | en |
| dc.description.abstract | Gram-positive bacterial cell walls are characterised by the presence of a thick peptidoglycan layer which provides protection from extracellular stresses, maintains cell integrity and determines cell morphology, while it also serves as a foundation to anchor a number of crucial polymeric structures. For ovococcal species, including streptococci, enterococci and lactococci, such structures are represented by rhamnose-containing cell wall polysaccharides, which at least in some instances appear to serve as a functional replacement for wall teichoic acids. The biochemical composition of several streptococcal, lactococcal and enterococcal rhamnose-containing cell wall polysaccharides have been elucidated, while associated functional genomic analyses have facilitated the proposition of models for individual biosynthetic pathways. Here, we review the genomic loci which encode the enzymatic machinery to produce rhamnose-containing, cell wall-associated polysaccharide (Rha cwps) structures of the afore-mentioned ovococcal bacteria with particular emphasis on gene content, biochemical structure and common biosynthetic steps. Furthermore, we discuss the role played by these saccharidic polymers as receptors for bacteriophages and the important role phages play in driving Rha cwps diversification and evolution. | en |
| dc.description.status | Peer reviewed | en |
| dc.description.version | Published Version | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.citation | Lavelle, K., Sinderen, D.V. and Mahony, J. (2021) ‘Cell wall polysaccharides of Gram positive ovococcoid bacteria and their role as bacteriophage receptors’, Computational and Structural Biotechnology Journal, 19, pp. 4018–4031. doi: 10.1016/j.csbj.2021.07.011 | en |
| dc.identifier.doi | 10.1016/j.csbj.2021.07.011 | en |
| dc.identifier.endpage | 4031 | en |
| dc.identifier.issn | 2001-0370 | en |
| dc.identifier.journaltitle | Computational and Structural Biotechnology Journal | en |
| dc.identifier.startpage | 4018 | en |
| dc.identifier.uri | https://hdl.handle.net/10468/15277 | |
| dc.identifier.volume | 19 | en |
| dc.language.iso | en | en |
| dc.publisher | Elsevier | en |
| dc.relation.ispartof | Computational and Structural Biotechnology Journal | en |
| dc.relation.project | info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/ | en |
| dc.relation.project | info:eu-repo/grantAgreement/SFI/SFI Starting Investigator Research Grant (SIRG)/15/SIRG/3430/IE/Phage-host interactome of the dairy bacterium Streptococcus thermophilus (PHIST)/ | en |
| dc.rights | © 2021 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) | en |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en |
| dc.subject | Lactococcus | en |
| dc.subject | Streptococcus | en |
| dc.subject | Staphylococcus | en |
| dc.subject | Enterococcus | en |
| dc.subject | Cell envelope | en |
| dc.subject | Rhamnose-glucose polymers | en |
| dc.subject | Phage-host interactions | en |
| dc.title | Cell wall polysaccharides of Gram positive ovococcoid bacteria and their role as bacteriophage receptors | en |
| dc.type | Article (peer-reviewed) | en |
| dc.type | journal-article | en |
| oaire.citation.volume | 19 | en |
