A functional analysis of Rab11a and Rab11b in endosomal recycling

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dc.check.embargoformatEmbargo not applicable (If you have not submitted an e-thesis or do not want to request an embargo)en
dc.check.infoNot applicableen
dc.check.opt-outYesen
dc.check.reasonThis thesis is due for publication or the author is actively seeking to publish this materialen
dc.check.typeNo Embargo Required
dc.contributor.advisorMcCaffrey, Maryen
dc.contributor.authorArtemiuk, Patrycja A.
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2019-04-17T12:37:18Z
dc.date.available2019-04-17T12:37:18Z
dc.date.issued2019
dc.date.submitted2019
dc.description.abstractRab11 GTPases are a family of three monomeric G proteins which are involved in a number of cellular processes including cell division, cell migration and cargo trafficking. Rab11a and Rab11b share over 89% sequence similarity, while Rab25 is approximately 60% similar to Rab11a and Rab11b. Both Rab11a and Rab11b are ubiquitously expressed proteins while the expression of Rab25 is restricted to the epithelial cells. Rab11 GTPases have been implicated in a number of diseases including: neurological disorders, pathogenic infections, diabetes and cancer. The majority of research conducted on the Rab11 GTPase family has focused on Rab11a, whereas Rab11b remains the least well characterised member of this family. Thus, a functional analysis of Rab11a and Rab11b was conducted using RNAi gene knockdown and compared with developed stable cell line expressing the wild-type and dominant negative mutants of these GTPases. We observed that Rab11a and Rab11b differentially regulate protein levels of Epidermal Growth Factor Receptor (EGFR), Her2 and E-cadherin. Furthermore, a number of other observations indicating that Rab11a and Rab11b have distinct cellular roles have been observed. Together these suggest that Rab11a and Rab11b have non-redundant and non-overlapping functions in the cell.en
dc.description.statusNot peer revieweden
dc.description.versionAccepted Version
dc.format.mimetypeapplication/pdfen
dc.identifier.citationArtemiuk, P. A. 2019. A functional analysis of Rab11a and Rab11b in endosomal recycling. PhD Thesis, University College Cork.en
dc.identifier.urihttps://hdl.handle.net/10468/7782
dc.language.isoenen
dc.publisherUniversity College Corken
dc.rights© 2019, Patrycja Anna Artemiuk.en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/en
dc.subjectRab11 familyen
dc.subjectRab GTPasesen
dc.subjectEpidermal growth factor receptorsen
dc.subjectEndosomal recyclingen
dc.thesis.opt-outtrue
dc.titleA functional analysis of Rab11a and Rab11b in endosomal recyclingen
dc.typeDoctoral thesisen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnamePhDen
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