Associations between the nutrient profiling system underlying the nutri-score nutrition label and biomarkers of chronic low-grade inflammation: a cross-sectional analysis of a middle- to older-aged population

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dc.contributor.authorMillar, Seán R.
dc.contributor.authorNavarro, Pilar
dc.contributor.authorHarrington, Janas M.
dc.contributor.authorPerry, Ivan J.
dc.contributor.authorPhillips, Catherine M.
dc.contributor.funderHealth Research Boarden
dc.date.accessioned2022-11-23T16:00:19Z
dc.date.available2022-11-23T16:00:19Z
dc.date.issued2022
dc.date.updated2022-11-23T15:23:30Z
dc.description.abstractLow-grade systemic inflammation is associated with a range of conditions. Diet may modulate inflammation and public health strategies are needed to guide consumers' dietary choices and help prevent diet-related disease. The Food Standards Agency nutrient profiling system (FSAm-NPS) constitutes the basis of the five-colour front-of-pack Nutri-Score labelling system. No study to date has examined FSAm-NPS dietary index associations with biomarkers of inflammation. Therefore, our objective was to test relationships between the FSAm-NPS and a range of inflammatory biomarkers in a cross-sectional sample of 2006 men and women aged 46-73 years. Individual participant FSAm-NPS scores were derived from food frequency questionnaires. Pro-inflammatory cytokine, adipocytokine, acute-phase response protein, coagulation factor and white blood cell count concentrations were determined. Correlation and linear regression analyses were used to examine FSAm-NPS relationships with biomarker levels. In crude and adjusted analyses, higher FSAm-NPS scores, reflecting poorer nutritional quality, were consistently and positively associated with biomarkers. In fully adjusted models, significant associations with concentrations of complement component 3, c-reactive protein, interleukin 6, tumour necrosis factor alpha, resistin, white blood cell count, neutrophils, eosinophils and the neutrophil-to-lymphocyte ratio persisted. These results suggest that dietary quality, determined by Nutri-Score rating, is associated with inflammatory biomarkers related to health.en
dc.description.sponsorshipHealth Research Board (Grant number HRC/2007/13)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMillar, S. R, Navarro, P., Harrington, J. M., Perry, I. J. and Phillips, C. M. (2022) 'Associations between the nutrient profiling system underlying the nutri-score nutrition label and biomarkers of chronic low-grade inflammation: a cross-sectional analysis of a middle- to older-aged population', Nutrients, 14 (15), (11 pp). doi: 10.3390/nu14153122en
dc.identifier.doi10.3390/nu14153122en
dc.identifier.endpage11en
dc.identifier.issued15en
dc.identifier.journaltitleNutrientsen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/13877
dc.identifier.volume14en
dc.language.isoenen
dc.publisherMDPIen
dc.rights© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectNutri-scoreen
dc.subjectDieten
dc.subjectChronicen
dc.subjectInflammationen
dc.subjectBiomarkersen
dc.titleAssociations between the nutrient profiling system underlying the nutri-score nutrition label and biomarkers of chronic low-grade inflammation: a cross-sectional analysis of a middle- to older-aged populationen
dc.typeArticle (peer-reviewed)en
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