Early identification of frailty: Developing an international delphi consensus on pre-frailty

Simple item page
dc.contributor.authorSezgin, Duygu
dc.contributor.authorO'Donovan, Mark
dc.contributor.authorWoo, Jean
dc.contributor.authorBandeen-Roche, Karen
dc.contributor.authorLiotta, Giuseppe
dc.contributor.authorFairhall, Nicola
dc.contributor.authorRodríguez-Laso, Angel
dc.contributor.authorApóstolo, João
dc.contributor.authorClarnette, Roger
dc.contributor.authorHolland, Carol
dc.contributor.authorRoller-Wirnsberger, Regina
dc.contributor.authorIllario, Maddalena
dc.contributor.authorMañas, Leocadio Rodrí­guez
dc.contributor.authorVollenbroek-Hutten, Miriam
dc.contributor.authorDoğu, Burcu Balam
dc.contributor.authorBalci, Cafer
dc.contributor.authorPernasq, Francisco Orfil
dc.contributor.authorPaul, Constança
dc.contributor.authorAhern, Emer
dc.contributor.authorRomero-Ortuno, Roman
dc.contributor.authorMolloy, William
dc.contributor.authorCooney, Maria Therese
dc.contributor.authorO'Shea, Diarmuid
dc.contributor.authorCooke, John
dc.contributor.authorLang, Deirdre
dc.contributor.authorHendry, Anne
dc.contributor.authorKennelly, Siobhán
dc.contributor.authorRockwood, Kenneth
dc.contributor.authorClegg, Andrew
dc.contributor.authorLiew, Aaron
dc.contributor.authorO'Caoimh, Rónán
dc.contributor.funderEuropean Commissionen
dc.date.accessioned2022-01-18T15:08:55Z
dc.date.available2022-01-18T15:08:55Z
dc.date.issued2021-11-20
dc.date.updated2022-01-18T14:52:54Z
dc.description.abstractBackground: Frailty is associated with a prodromal stage called pre-frailty, a potentially reversible and highly prevalent intermediate state before frailty becomes established. Despite being widely-used in the literature and increasingly in clinical practice, it is poorly understood Objective: To establish consensus on the construct and approaches to diagnose and manage pre-frailty. Methods: We conducted a modified (electronic, two-round) Delphi consensus study. The questionnaire included statements concerning the concept, aspects and causes, types, mechanism, assessment, consequences, prevention and management of pre-frailty. Qualitative and quantitative analysis methods were employed. An agreement level of 70% was applied. Results: Twenty-three experts with different backgrounds from 12 countries participated. In total, 70 statements were circulated in Round 1. Of these, 52.8% were accepted. Following comments, 51 statements were recirculated in Round 2 and 92.1% were accepted. It was agreed that physical and non-physical factors including psychological and social capacity are involved in the development of pre-frailty, potentially adversely affecting health and health-related quality of life. Experts considered pre-frailty to be an age-associated multi factorial, multi-dimensional, and non-linear process that does not inevitably lead to frailty. It can be reversed or attenuated by targeted interventions. Brief, feasible, and validated tools and multidimensional assessment are recommended to identify pre-frailty. Conclusions: : Consensus suggests that pre-frailty lies along the frailty continuum. It is a multidimensional risk state associated with one or more of physical impairment, cognitive decline, nutritional deficiencies and socioeconomic disadvantages, predisposing to the development of frailty. More research is needed to agree an operational definition and optimal management strategies.en
dc.description.sponsorshipEuropean Commission (‘ADVANTAGE’ Joint Action on Frailty Prevention, grant number 724099)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid104586en
dc.identifier.citationSezgin, D., O'Donovan, M., Woo, J., Bandeen-Roche, K., Liotta, G., Fairhall, N., Rodriguez-Laso, A., Apostolo, J., Clarnette, R., Holland, C., Roller-Wirnsberger, R., Illario, M., Manas, L. R., Vollenbroek-Hutten, M., Dogu, B. B., Balci, C., Pernas, F. O., Paul, C., Ahern, E., Romero-Ortuno, R., Molloy, W., Cooney, M. T., O'Shea, D., Cooke, J., Lang, D., Hendry, A., Kennelly, S., Rockwood, K., Clegg, A., Liew, A. and O'Caoimh, R. (2021) 'Early identification of frailty: Developing an international delphi consensus on pre-frailty', Archives of Gerontology and Geriatrics, 99, 104586 (8pp). doi: 10.1016/j.archger.2021.104586en
dc.identifier.doi10.1016/j.archger.2021.104586en
dc.identifier.endpage8en
dc.identifier.issn0167-4943
dc.identifier.journaltitleArchives of Gerontology and Geriatricsen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/12411
dc.identifier.volume99en
dc.language.isoenen
dc.publisherElsevier B.V.en
dc.rights© 2021, Elsevier B.V. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectFrailtyen
dc.subjectGeriatric assessmenten
dc.subjectConsensusen
dc.subjectPre-frailtyen
dc.subjectOlder peopleen
dc.subjectDelphien
dc.subjectDefinitionen
dc.titleEarly identification of frailty: Developing an international delphi consensus on pre-frailtyen
dc.typeArticle (peer-reviewed)en
Files
Original bundle
Now showing 1 - 3 of 3
Thumbnail Image
Name:
manuscript_prefrailty_delphi_pre-publication_draft.pdf
Size:
367.57 KB
Format:
Adobe Portable Document Format
Description:
Accepted Version
Download
Thumbnail Image
Name:
1-s2.0-S0167494321002491-mmc1.docx
Size:
42.4 KB
Format:
Microsoft Word XML
Description:
Supplementary Materials
Download
Thumbnail Image
Name:
manuscript prefrailty delphi pre-publication draft.docx
Size:
86.67 KB
Format:
Microsoft Word XML
Description:
Author's Original Accepted Version
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Medicine - Journal Articles
Centre for Gerontology and Rehabilitation - Journal Articles