Evolution and expression of the immune system of a facultatively anadromous salmonid

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dc.contributor.authorColgan, Thomas J.
dc.contributor.authorMoran, Peter A.
dc.contributor.authorArcher, Louise C.
dc.contributor.authorWynne, Robert
dc.contributor.authorHutton, Stephen A.
dc.contributor.authorMcGinnity, Philip
dc.contributor.authorReed, Thomas E.
dc.contributor.funderHorizon 2020en
dc.contributor.funderEuropean Research Councilen
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderMarine Institute, Irelanden
dc.contributor.funderGovernment of Irelanden
dc.date.accessioned2021-07-01T14:15:49Z
dc.date.available2021-07-01T14:15:49Z
dc.date.issued2021-02-26
dc.date.updated2021-07-01T11:31:30Z
dc.description.abstractVertebrates have evolved a complex immune system required for the identification of and coordinated response to harmful pathogens. Migratory species spend periods of their life-cycle in more than one environment, and their immune system consequently faces a greater diversity of pathogens residing in different environments. In facultatively anadromous salmonids, individuals may spend parts of their life-cycle in freshwater and marine environments. For species such as the brown trout Salmo trutta, sexes differ in their life-histories with females more likely to migrate to sea while males are more likely to stay and complete their life-cycle in their natal river. Salmonids have also undergone a lineage-specific whole genome duplication event, which may provide novel immune innovations but our current understanding of the differences in salmonid immune expression between the sexes is limited. We characterized the brown trout immune gene repertoire, identifying a number of canonical immune genes in non-salmonid teleosts to be duplicated in S. trutta, with genes involved in innate and adaptive immunity. Through genome-wide transcriptional profiling (“RNA-seq”) of male and female livers to investigate sex differences in gene expression amplitude and alternative splicing, we identified immune genes as being generally male-biased in expression. Our study provides important insights into the evolutionary consequences of whole genome duplication events on the salmonid immune gene repertoire and how the sexes differ in constitutive immune expression.en
dc.description.sponsorshipMarine Institute, Ireland (grant-in-aid (RESPI/FS/16/01) from the Marine Institute (Ireland) as part of the Marine Research Programme by the Irish Government)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid568729en
dc.identifier.citationColgan, T. J., Moran, P. A., Archer, L. C., Wynne, R., Hutton, S. A., McGinnity, P. and Reed, T. E. (2021) 'Evolution and Expression of the Immune System of a Facultatively Anadromous Salmonid', Frontiers in Immunology, 12, 568729 (17 pp). doi: 10.3389/fimmu.2021.568729en
dc.identifier.doi10.3389/fimmu.2021.568729en
dc.identifier.endpage17en
dc.identifier.issn1664-3224
dc.identifier.journaltitleFrontiers In Immunologyen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/11526
dc.identifier.volume12en
dc.language.isoenen
dc.publisherFrontiers Mediaen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::ERC::ERC-STG/639192/EU/Alternative life histories: linking genes to phenotypes to demography/ALHen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Investigator Programme/15/IA/3028/IE/Wild farmed interactions in a changing world: formulation of a predictive methodology to inform environmental best practice to secure long-term sustainability of global wild and farm fish populations/en
dc.relation.urihttps://www.frontiersin.org/articles/10.3389/fimmu.2021.568729
dc.rights© 2021 Colgan, Moran, Archer, Wynne, Hutton, McGinnity and Reed. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectFacultatively anadromousen
dc.subjectImmunityen
dc.subjectGene expressionen
dc.subjectGene duplicationsen
dc.subjectSexual dimorphismen
dc.subjectSalmonidsen
dc.titleEvolution and expression of the immune system of a facultatively anadromous salmoniden
dc.typeArticle (peer-reviewed)en
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