Exploratory analysis of covariation of microbiota-derived vitamin K and cognition in older adults

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dc.contributor.authorMcCann, Angela
dc.contributor.authorJeffery, Ian B.
dc.contributor.authorOuliass, Bouchra
dc.contributor.authorFerland, Guylaine
dc.contributor.authorFu, Xueyen
dc.contributor.authorBooth, Sarah L.
dc.contributor.authorTran, Tam T. T.
dc.contributor.authorO'Toole, Paul W.
dc.contributor.authorO'Connor, Eibhlís M.
dc.contributor.funderUS Allen Foundationen
dc.contributor.funderDepartment of Agriculture, Food and the Marineen
dc.contributor.funderHealth Research Boarden
dc.contributor.funderIrish Heart Foundationen
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderAgricultural Research Serviceen
dc.date.accessioned2019-10-16T05:49:06Z
dc.date.available2019-10-16T05:49:06Z
dc.date.issued2019-09-13
dc.description.abstractBackground: Vitamin K has multiple important physiological roles, including blood coagulation and beneficial effects on myelin integrity in the brain. Some intestinal microbes possess the genes to produce vitamin K in the form of menaquinone (MK). MK appears in higher concentration in tissues, such as the brain, particularly MK4, than the dietary form of phylloquinone (PK). Lower PK concentrations have been reported in patients with Alzheimer disease while higher serum PK concentrations have been positively associated with verbal episodic memory. Despite knowledge of the importance of vitamin K for various health parameters, few studies have measured MK concentration and biosynthesis by gut commensals. Objective: The aim of the current study was to investigate the relation between genes involved in gut-microbiota derived MK, concentrations of MK isoforms, and cognitive function. Methods: Shotgun metagenomic sequencing of the gut microbiome of 74 elderly individuals with different cognitive ability levels was performed. From this, gene counts for microbial MK biosynthesis were determined. Associations between clusters of individuals, grouped based on a similar presence and prevalence of MK biosynthesis genes, and cognitive ability were investigated. Fecal MK concentrations were quantified by HPLC to investigate correlations with subject clusters. Results: Separation of subject groups defined by banded quantification of the genetic potential of their microbiome to biosynthesize MK was associated with significant differences in cognitive ability [assessed using the Mini-Mental State Examination (MMSE)]. Three MK isoforms were found to be positively associated with MMSE, along with the identification of key components of the MK pathway that drive this association. Although the causality and direction of these associations remain unknown, these findings justify further studies. Conclusions; This study provides evidence that although total concentrations of MK did not covary with cognition, certain MK isoforms synthesized by the gut microbiome, particularly the longer chains, are positively associated with cognition.en
dc.description.sponsorshipDepartment of Agriculture, Food and the Marine (Food Institute Research Measure (17F521)); SDA Agricultural Research Service (Cooperative Agreement No. 58-1950-7-707)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleidnqz220en
dc.identifier.citationMcCann, A., Jeffery, I. B., Ouliass, B., Ferland, G., Fu, X., Booth, S. L., Tran, T. T., O'Toole, P. W. and O'Connor, E. M. (2019) 'Exploratory analysis of covariation of microbiota-derived vitamin K and cognition in older adults', The American Journal of Clinical Nutrition. nqz220. (12pp.) DOI: 10.1093/ajcn/nqz220en
dc.identifier.doi10.1093/ajcn/nqz220en
dc.identifier.eissn1938-3207
dc.identifier.endpage12en
dc.identifier.issn0002-9165
dc.identifier.journaltitleAmerican Journal of Clinical Nutritionen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/8783
dc.language.isoenen
dc.publisherOxford University Pressen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Starting Investigator Research Grant (SIRG)/13/SIRG/2128/IE/Development of Knowledge Base Necessary for Novel Diagnostic and Therapeutic Pipeline for the Early Identification and Treatment of Rheumatoid Arthritis/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.relation.urihttps://academic.oup.com/ajcn/advance-article/doi/10.1093/ajcn/nqz220/5569648
dc.rights©American Society for Nutrition 2019. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectMicrobial menaquinone biosynthesisen
dc.subjectElderlyen
dc.subjectCognitionen
dc.subjectShotgun metagenomic sequencingen
dc.subjectVitamin Ken
dc.titleExploratory analysis of covariation of microbiota-derived vitamin K and cognition in older adultsen
dc.typeArticle (peer-reviewed)en
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