Reducing unnecessary biopsies using digital breast tomosynthesis and ultrasound in dense and nondense breasts

Simple item page
dc.contributor.authorHadadi, I.
dc.contributor.authorClarke, J.
dc.contributor.authorRae, W.
dc.contributor.authorMcEntee, Mark F.
dc.contributor.authorVincent, W.
dc.contributor.authorEkpo, E.
dc.date.accessioned2023-07-13T13:06:22Z
dc.date.available2023-07-13T13:06:22Z
dc.date.issued2022
dc.description.abstractAim: To compare digital breast tomosynthesis (DBT) and ultrasound in women recalled for assessment after a positive screening mammogram and assess the potential for each of these tools to reduce unnecessary biopsies. Methods: This data linkage study included 538 women recalled for assessment from January 2017 to December 2019. The association between the recalled mammographic abnormalities and breast density was analysed using the chi-square independence test. Relative risks and the number of recalled cases requiring DBT and ultrasound assessment to prevent one unnecessary biopsy were compared using the McNemar test. Results: Breast density significantly influenced recall decisions (p < 0.001). Ultrasound showed greater potential to decrease unnecessary biopsies than DBT: in entirely fatty (21% vs. 5%; p = 0.04); scattered fibroglandular (23% vs. 10%; p = 0.003); heterogeneously dense (34% vs. 7%; p < 0.001) and extremely dense (39% vs. 9%; p < 0.001) breasts. The number of benign cases needing assessment to prevent one unnecessary biopsy was significantly lower with ultrasound than DBT in heterogeneously dense (1.8 vs. 7; p < 0.001) and extremely dense (1.9 vs. 5.1; p = 0.03) breasts. Conclusion: Women with dense breasts are more likely to be recalled for assessment and have a false-positive biopsy. Women with dense breasts benefit more from ultrasound assessment than from DBT. en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationHadadi, I., Clarke, J., Rae, W., McEntee, M., Vincent, W. and Ekpo, E. (2022) 'Reducing unnecessary biopsies using digital breast tomosynthesis and ultrasound in dense and nondense breasts', Current Oncology, 29(8), pp.5508-5516. doi: 10.3390/curroncol29080435en
dc.identifier.doi10.3390/curroncol29080435
dc.identifier.endpage5516
dc.identifier.issn17187729
dc.identifier.issued8
dc.identifier.journaltitleCurrent Oncologyen
dc.identifier.startpage5508
dc.identifier.urihttps://hdl.handle.net/10468/14731
dc.identifier.volume29
dc.language.isoenen
dc.publisherMDPIen
dc.rights© 2022, the Authors. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectBenign biopsyen
dc.subjectBreast canceren
dc.subjectBreast densityen
dc.subjectDBTen
dc.subjectUltrasounden
dc.titleReducing unnecessary biopsies using digital breast tomosynthesis and ultrasound in dense and nondense breastsen
dc.typeArticle (peer-reviewed)en
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
curroncol-29-00435.pdf
Size:
253.83 KB
Format:
Adobe Portable Document Format
Description:
Published Version
Download
Collections
Medicine - Journal Articles