dc.contributor.author	Felice, Daniela
dc.contributor.author	Cryan, John F.
dc.contributor.author	O'Leary, Olivia F.
dc.date.accessioned	2022-01-20T14:10:14Z
dc.date.available	2022-01-20T14:10:14Z
dc.date.issued	2020-08-30
dc.date.updated	2022-01-20T13:53:54Z
dc.description.abstract	Gamma-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the brain, acts at the ionotropic GABAA and GABAC receptors, and the metabotropic GABAB receptor. This chapter summarizes the studies that have investigated the role of the GABAB receptor in stress-related psychiatric disorders including anxiety and mood disorders. Overall, clinical and preclinical evidences strongly suggest that the GABAB receptor is a therapeutic candidate for depression and anxiety disorders. However, the clinical development of GABAB receptor-based drugs to treat these disorders has been hampered by their potential side-effects, particularly those of agonists. Nevertheless, the discovery of novel GABAB receptor allosteric modulators, and increasing understanding of the influence of specific intracellular GABAB receptor-associated proteins on GABAB receptor activity, may now pave the way towards GABAB receptor therapeutics in the treatment of mood and anxiety disorders.	en
dc.description.status	Peer reviewed	en
dc.description.version	Accepted Version	en
dc.format.mimetype	application/pdf	en
dc.identifier.citation	Felice, D., Cryan, J. F. and O'Leary, O. F. (2020) 'GABAB receptors, anxiety and mood disorders', in Vlachou S. and Wickman K. (eds.) Behavioral Neurobiology of GABAB Receptor Function. Current Topics in Behavioral Neurosciences, vol. 52, pp. 241-265, Springer, Cham. doi: 10.1007/7854_2020_171	en
dc.identifier.doi	10.1007/7854_2020_171	en
dc.identifier.eissn	1866-3389
dc.identifier.endpage	265	en
dc.identifier.issn	1866-3370
dc.identifier.journaltitle	Current Topics in Behavioral Neurosciences	en
dc.identifier.startpage	241	en
dc.identifier.uri	https://hdl.handle.net/10468/12431
dc.identifier.volume	52	en
dc.language.iso	en	en
dc.publisher	Springer	en
dc.relation.ispartof	Behavioral Neurobiology of GABAB Receptor Function
dc.rights	© 2020, Springer Nature Switzerland AG. This is a post-peer-review, pre-copyedit version of an article published in Current Topics in Behavioral Neurosciences. The final authenticated version is available online at: https://doi.org/10.1007/7854_2020_171	en
dc.subject	Anxiety	en
dc.subject	Depression	en
dc.subject	GABAB receptor	en
dc.subject	Hippocampal neurogenesis	en
dc.subject	Mood	en
dc.subject	Stress	en
dc.subject	Stress resilience	en
dc.title	GABAB receptors, anxiety and mood disorders	en
dc.type	Article (peer-reviewed)	en

GABAB receptors, anxiety and mood disorders

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