An ultrasonically-powered system for 1.06mm3 implantable optogenetics and drug delivery dust

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dc.contributor.authorLaursen, Kjelden
dc.contributor.authorZamani, Miladen
dc.contributor.authorRezaeiyan, Yasseren
dc.contributor.authorHosseini, Seyedsinaen
dc.contributor.authorMondal, Tanmayen
dc.contributor.authorCorbett, Brianen
dc.contributor.authorOuagazzal, Abdel Mouttaliben
dc.contributor.authorAmalric, Marianneen
dc.contributor.authorMoradi, Farshaden
dc.contributor.funderHorizon 2020en
dc.date.accessioned2023-09-06T13:38:33Z
dc.date.available2023-09-06T13:38:33Z
dc.date.issued2023-06-23en
dc.description.abstractThis paper presents an ultrasonically powered micro-system for deep tissue optogenetic stimulation. The developed system is composed of a Base for Powering and Controlling (BPC) and an implantable Dust for optogenetics and drug delivery. The Dust consists of a piezoelectric crystal, a rectifier chip, and a micro-scale custom-designed light-emitting-diode (μLED) integrated, miniaturized, and envisioned to be used for freely moving animal studies. The proposed Dust operates in frequencies up to 5 MHz, power levels in the 0–10 mW range, achieves start-up within 1.8 μs at 2.9 MHz operating frequency at 14.4 mW/mm2 ultrasound power density, and 98.1% chip efficiency at 2 mW input power. With the BPC implemented and attached to (500 μm)3 PZT4 crystals, set to 60 V at 2.8 MHz operating frequency at 3 mm distance in demineralized water, the dust delivered up to 6 mW to its load (μLED for optogenetics), which translates to 0.11% total system efficiency.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationLaursen, K., Zamani, M., Rezaeiyan, Y., Hosseini, S., Mondal, T., Corbett, B., Ouagazzal, A. M., Amalric, M. and Moradi, F. (2023) 'An ultrasonically-powered system for 1.06 mm3 implantable optogenetics and drug delivery dust', IEEE Transactions on Circuits and Systems II: Express Briefs, 70(10), pp, 3937-3941. doi: 10.1109/TCSII.2023.3289028en
dc.identifier.doi10.1109/tcsii.2023.3289028en
dc.identifier.eissn1558-3791en
dc.identifier.endpage3941
dc.identifier.issn1549-7747en
dc.identifier.issued10
dc.identifier.journaltitleIEEE Transactions on Circuits and Systems II: Express Briefsen
dc.identifier.startpage3937
dc.identifier.urihttps://hdl.handle.net/10468/14929
dc.identifier.volume70
dc.language.isoenen
dc.publisherInstitute of Electrical and Electronics Engineers (IEEE)en
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::RIA/767092/EU/in vivo optogeneticS, elecTrophysiology and phArmacology with an ultRasonically-powered DUST for Parkinson's Disease/STARDUSTen
dc.rights© 2023, IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.en
dc.subjectDusten
dc.subjectOptogenetic stimulationen
dc.subjectRectifieren
dc.subjectPiezoelectricen
dc.subjectUltrasonic power transferen
dc.titleAn ultrasonically-powered system for 1.06mm3 implantable optogenetics and drug delivery dusten
dc.typeArticle (peer-reviewed)en
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