Fungal β-glucan-facilitated cross-feeding activities between Bacteroides and Bifidobacterium species

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dc.contributor.authorFernandez-Julia, Pedro J.en
dc.contributor.authorBlack, Gary W.en
dc.contributor.authorCheung, Williamen
dc.contributor.authorvan Sinderen, Douween
dc.contributor.authorMunoz-Munoz, Joseen
dc.contributor.funderMarlow Foods Ltd.en
dc.contributor.funderNorthumbria Universityen
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2023-11-13T14:48:01Z
dc.date.available2023-11-13T14:48:01Z
dc.date.issued2023en
dc.description.abstractThe human gut microbiota (HGM) is comprised of a very complex network of microorganisms, which interact with the host thereby impacting on host health and well-being. β-glucan has been established as a dietary polysaccharide supporting growth of particular gut-associated bacteria, including members of the genera Bacteroides and Bifidobacterium, the latter considered to represent beneficial or probiotic bacteria. However, the exact mechanism underpinning β-glucan metabolism by gut commensals is not fully understood. We show that mycoprotein represents an excellent source for β-glucan, which is consumed by certain Bacteroides species as primary degraders, such as Bacteroides cellulosilyticus WH2. The latter bacterium employs two extracellular, endo-acting enzymes, belonging to glycoside hydrolase families 30 and 157, to degrade mycoprotein-derived β-glucan, thereby releasing oligosaccharides into the growth medium. These released oligosaccharides can in turn be utilized by other gut microbes, such asBifidobacterium and Lactiplantibacillus, which thus act as secondary degraders. We used a cross-feeding approach to track how both species are able to grow in co-culture.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid576en
dc.identifier.citationFernandez-Julia, P., Black, G. W., Cheung, W., Van Sinderen, D., and Munoz-Munoz, J. (2023) 'Fungal β-glucan-facilitated cross-feeding activities between Bacteroides and Bifidobacterium species', Communications Biology, 6(1), 576 (14pp). doi: 10.1038/s42003-023-04970-4en
dc.identifier.doi10.1038/s42003-023-04970-4en
dc.identifier.endpage14en
dc.identifier.issn2399-3642en
dc.identifier.journaltitleCommunications Biologyen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/15225
dc.identifier.volume6en
dc.language.isoenen
dc.publisherNature Researchen
dc.relation.ispartofCommunications Biologyen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.rights© The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectHuman gut microbiotaen
dc.subjectHGMen
dc.subjectβ-glucanen
dc.subjectBacteroidesen
dc.subjectBifidobacteriumen
dc.titleFungal β-glucan-facilitated cross-feeding activities between Bacteroides and Bifidobacterium speciesen
dc.typeArticle (peer-reviewed)en
dc.typejournal-articleen
oaire.citation.issue1en
oaire.citation.volume6en
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