dc.contributor.author	Upadrasta, Aditya
dc.contributor.author	O'Sullivan, Lisa
dc.contributor.author	O'Sullivan, Orla
dc.contributor.author	Sexton, Noel
dc.contributor.author	Lawlor, Peadar G.
dc.contributor.author	Hill, Colin
dc.contributor.author	Fitzgerald, Gerald F.
dc.contributor.author	Stanton, Catherine
dc.contributor.author	Ross, R. Paul
dc.contributor.funder	Enterprise Ireland
dc.contributor.funder	Science Foundation Ireland
dc.contributor.funder	European Commission
dc.date.accessioned	2016-02-17T11:45:32Z
dc.date.available	2016-02-17T11:45:32Z
dc.date.issued	2013
dc.description.abstract	Background: There is an increasing need for alternatives to antibiotics for promoting animal health, given the increasing problems associated with antibiotic resistance. In this regard, we evaluated spent cider yeast as a potential probiotic for modifying the gut microbiota in weanling pigs using pyrosequencing of 16S rRNA gene libraries. Methodology and Principal Findings: Piglets aged 24-26 days were assigned to one of two study groups; control (n = 12) and treatment (n = 12). The control animals were fed with a basal diet and the treatment animals were fed with basal diet in combination with cider yeast supplement (500 ml cider yeast containing similar to ∼7.6 log CFU/ml) for 21 days. Faecal samples were collected for 16s rRNA gene compositional analysis. 16S rRNA compositional sequencing analysis of the faecal samples collected from day 0 and day 21 revealed marked differences in microbial diversity at both the phylum and genus levels between the control and treatment groups. This analysis confirmed that levels of Salmonella and Escherichia were significantly decreased in the treatment group, compared with the control (P<0.001). This data suggest a positive influence of dietary supplementation with live cider yeast on the microbial diversity of the pig distal gut. Conclusions/Significance: The effect of dietary cider yeast on porcine gut microbial communities was characterized for the first time using 16S rRNA gene compositional sequencing. Dietary cider yeast can potentially alter the gut microbiota, however such changes depend on their endogenous microbiota that causes a divergence in relative response to that given diet.	en
dc.description.sponsorship	Enterprise Ireland (Commercialisation Fund CFTD/05/117); European Commission (European Research and Development Fund)	en
dc.description.status	Peer reviewed	en
dc.description.version	Published Version	en
dc.format.mimetype	application/pdf	en
dc.identifier.articleid	e75714
dc.identifier.citation	Upadrasta A, O’Sullivan L, O’Sullivan O, Sexton N, Lawlor PG, Hill C, et al. (2013) The Effect of Dietary Supplementation with Spent Cider Yeast on the Swine Distal Gut Microbiome. PLoS ONE 8(10): e75714. doi:10.1371/journal.pone.0075714
dc.identifier.doi	10.1371/journal.pone.0075714
dc.identifier.issn	1932-6203
dc.identifier.issued	10	en
dc.identifier.journaltitle	PLOS ONE	en
dc.identifier.uri	https://hdl.handle.net/10468/2363
dc.identifier.volume	8	en
dc.language.iso	en	en
dc.publisher	Public Library of Science	en
dc.rights	© 2015 Upadrasta et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited	en
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	en
dc.subject	Porcine gastrointestinal tract	en
dc.subject	Weanling pigs	en
dc.subject	Nutrient digestibility	en
dc.subject	High-throughput	en
dc.subject	Live yeast	en
dc.subject	Sp. nov.	en
dc.subject	Performance	en
dc.subject	Salmonella	en
dc.subject	Bacteria	en
dc.subject	Culture	en
dc.title	The effect of dietary supplementation with spent cider yeast on the swine distal gut microbiome	en
dc.type	Article (peer-reviewed)	en

The effect of dietary supplementation with spent cider yeast on the swine distal gut microbiome

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