Mutagenesis by microbe: The role of the microbiota in shaping the cancer genome
dc.contributor.author | Barrett, Maurice P. J. | |
dc.contributor.author | Hand, Collette K. | |
dc.contributor.author | Shanahan, Fergus | |
dc.contributor.author | Murphy, Thomas | |
dc.contributor.author | O'Toole, Paul W. | |
dc.contributor.funder | Science Foundation Ireland | en |
dc.contributor.funder | Health Research Board | en |
dc.date.accessioned | 2020-04-02T10:56:10Z | |
dc.date.available | 2020-04-02T10:56:10Z | |
dc.date.issued | 2020-02-20 | |
dc.date.updated | 2020-04-02T10:31:00Z | |
dc.description.abstract | Cancers arise through the process of somatic evolution fueled by the inception of somatic mutations. We lack a complete understanding of the sources of these somatic mutations. Humans host a vast repertoire of microbes collectively known as the microbiota. The microbiota plays a role in altering the tumor microenvironment and proliferation. In addition, microbes have been shown to elicit DNA damage which provides the driver for somatic mutations. An understanding of microbiota-driven mutational mechanisms would contribute to a more complete understanding of the origins of the cancer genome. Here, we review the modes by which microbes stimulate DNA damage and the effect of these phenomena upon the cancer genomic architecture, specifically in the form of mutational spectra and mutational signatures. | en |
dc.description.sponsorship | Health Research Board (Grant ILP-POR-2017-034) | en |
dc.description.status | Peer reviewed | en |
dc.description.version | Accepted Version | en |
dc.format.mimetype | application/pdf | en |
dc.identifier.citation | Barrett, M., Hand, C. K., Shanahan, F., Murphy, T. and O'Toole, P. W. (2020) 'Mutagenesis by microbe: The role of the microbiota in shaping the cancer genome', Trends in Cancer, 6(4), 277-287. doi: 10.1016/j.trecan.2020.01.019 | en |
dc.identifier.doi | 10.1016/j.trecan.2020.01.019 | en |
dc.identifier.eissn | 2405-8033 | |
dc.identifier.endpage | 287 | en |
dc.identifier.issn | 2405-8025 | |
dc.identifier.issued | 4 | en |
dc.identifier.journaltitle | Trends in Cancer | en |
dc.identifier.startpage | 277 | en |
dc.identifier.uri | https://hdl.handle.net/10468/9809 | |
dc.identifier.volume | 6 | en |
dc.language.iso | en | en |
dc.publisher | Elsevier Inc. | en |
dc.relation.project | info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/ | en |
dc.relation.uri | https://doi.org/10.1016/j.trecan.2020.01.019 | en |
dc.rights | © 2020, Elsevier Inc. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license. | en |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | en |
dc.subject | Microbiota | en |
dc.subject | Microbiome | en |
dc.subject | DNA damage | en |
dc.subject | Mutational mechanism | en |
dc.subject | Mutational signatures | en |
dc.title | Mutagenesis by microbe: The role of the microbiota in shaping the cancer genome | en |
dc.type | Article (peer-reviewed) | en |
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