Mutagenesis by microbe: The role of the microbiota in shaping the cancer genome

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dc.contributor.authorBarrett, Maurice P. J.
dc.contributor.authorHand, Collette K.
dc.contributor.authorShanahan, Fergus
dc.contributor.authorMurphy, Thomas
dc.contributor.authorO'Toole, Paul W.
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderHealth Research Boarden
dc.date.accessioned2020-04-02T10:56:10Z
dc.date.available2020-04-02T10:56:10Z
dc.date.issued2020-02-20
dc.date.updated2020-04-02T10:31:00Z
dc.description.abstractCancers arise through the process of somatic evolution fueled by the inception of somatic mutations. We lack a complete understanding of the sources of these somatic mutations. Humans host a vast repertoire of microbes collectively known as the microbiota. The microbiota plays a role in altering the tumor microenvironment and proliferation. In addition, microbes have been shown to elicit DNA damage which provides the driver for somatic mutations. An understanding of microbiota-driven mutational mechanisms would contribute to a more complete understanding of the origins of the cancer genome. Here, we review the modes by which microbes stimulate DNA damage and the effect of these phenomena upon the cancer genomic architecture, specifically in the form of mutational spectra and mutational signatures.en
dc.description.sponsorshipHealth Research Board (Grant ILP-POR-2017-034)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationBarrett, M., Hand, C. K., Shanahan, F., Murphy, T. and O'Toole, P. W. (2020) 'Mutagenesis by microbe: The role of the microbiota in shaping the cancer genome', Trends in Cancer, 6(4), 277-287. doi: 10.1016/j.trecan.2020.01.019en
dc.identifier.doi10.1016/j.trecan.2020.01.019en
dc.identifier.eissn2405-8033
dc.identifier.endpage287en
dc.identifier.issn2405-8025
dc.identifier.issued4en
dc.identifier.journaltitleTrends in Canceren
dc.identifier.startpage277en
dc.identifier.urihttps://hdl.handle.net/10468/9809
dc.identifier.volume6en
dc.language.isoenen
dc.publisherElsevier Inc.en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.relation.urihttps://doi.org/10.1016/j.trecan.2020.01.019en
dc.rights© 2020, Elsevier Inc. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectMicrobiotaen
dc.subjectMicrobiomeen
dc.subjectDNA damageen
dc.subjectMutational mechanismen
dc.subjectMutational signaturesen
dc.titleMutagenesis by microbe: The role of the microbiota in shaping the cancer genomeen
dc.typeArticle (peer-reviewed)en
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