Tracking cocrystallization of active pharmaceutical ingredients with Bbenzoic acid coformer using Broadband Acoustic resonance Dissolution Spectroscopy (BARDS)

dc.contributor.authorKent, Christopher
dc.contributor.authorRao Khandavilli, Udaya B. Rao
dc.contributor.authorAlfarsi, Anas
dc.contributor.authorHanna-Brown, Melissa
dc.contributor.authorMcSweeney, Seán
dc.contributor.authorKrüse, Jacob
dc.contributor.authorLawrence, Simon E.
dc.contributor.authorFitzpatrick, Dara
dc.date.accessioned2020-02-13T15:49:19Z
dc.date.available2020-02-13T15:49:19Z
dc.date.issued2018-09-18
dc.date.updated2020-02-13T15:41:31Z
dc.description.abstractThis study investigates the use of Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS) as a detection method for the formation of cocrystals. BARDS is a novel approach that uses reproducible changes in the compressibility of a solvent as a sample dissolves to characterize and differentiate between materials and in this case cocrystallization. Two cocrystal systems with a 1:1 stoichiometry were examined, which used benzoic acid as a coformer with isonicotinamide and with theophylline. Cocrystals were prepared using dry and wet milling for periods from 1 to 40 min, and samples were analyzed using infrared spectroscopy, powder X-ray diffraction, and BARDS. Comparison of the BARDS data with the IR and PXRD data cross-validated the BARDS results. This study shows that BARDS can be used to rapidly assess the formation of these cocrystals at-line when milling or as a relatively low cost tool in preformulation product development. The data can also be used to gauge the unique entrained gas and gas volume generation of the cocrystal samples during dissolution and their dissolution kinetics.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationKent, C., Rao Khandavilli, U. B., Alfarsi, A., Hanna-Brown, M., McSweeney, S., Krüse, J., Lawrence, S. and Fitzpatrick, D. (2018) 'Tracking Cocrystallization of Active Pharmaceutical Ingredients with Benzoic Acid Coformer Using Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS)', Crystal Growth & Design, 18(11), pp. 6528-6537. doi: 10.1021/acs.cgd.8b00668en
dc.identifier.doi10.1021/acs.cgd.8b00668en
dc.identifier.endpage6537en
dc.identifier.issn1528-7483
dc.identifier.journaltitleCrystal Growth & Designen
dc.identifier.startpage6528en
dc.identifier.urihttps://hdl.handle.net/10468/9648
dc.identifier.volume18en
dc.language.isoenen
dc.publisherAmerican Chemical Societyen
dc.relation.urihttps://pubs.acs.org/doi/10.1021/acs.cgd.8b00668
dc.rights© 2018 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth & Design, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/pdf/10.1021/acs.cgd.8b00668en
dc.subjectIsonicotinamideen
dc.subjectTheophyllineen
dc.subjectAcoustic spectroscopyen
dc.subjectDissolutionen
dc.subjectInfrared spectroscopyen
dc.subjectMilling (machining)en
dc.subjectBenzoic aciden
dc.titleTracking cocrystallization of active pharmaceutical ingredients with Bbenzoic acid coformer using Broadband Acoustic resonance Dissolution Spectroscopy (BARDS)en
dc.typeArticle (peer-reviewed)en
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