Early-life stress leads to sex-dependent changes in pubertal timing in rats that are reversed by a probiotic formulation.

dc.check.date2019-07-24
dc.check.infoAccess to this article is restricted until 12 months after publication by request of the publisher.en
dc.contributor.authorCowan, Caitlin S. M.
dc.contributor.authorRichardson, Rick
dc.contributor.funderAustralian Research Councilen
dc.contributor.funderNational Health and Medical Research Councilen
dc.contributor.funderPetre Foundationen
dc.contributor.funderUniversity of New South Walesen
dc.date.accessioned2019-02-06T09:57:59Z
dc.date.available2019-02-06T09:57:59Z
dc.date.issued2018-07-24
dc.date.updated2019-02-05T15:05:50Z
dc.description.abstractPuberty marks the beginning of a period of dramatic physical, hormonal, and social change. This instability has made adolescence infamous as a time of "storm and stress" and it is well-established that stress during adolescence can be particularly damaging. However, prior stress may also shape the adolescent experience. In the present series of experiments, we observed sex-specific effects of early-life maternal separation stress on the timing of puberty onset in the rat. Specifically, stressed females exhibited earlier pubertal onset compared to standard-reared females, whereas stressed males matured later than their standard-reared counterparts. Further, we demonstrated that a probiotic treatment restores the normative timing of puberty onset in rodents of both sexes. These results are in keeping with previous findings that probiotics reverse stress-induced changes in learned fear behaviors and stress hormone levels, highlighting the remarkable and wide-ranging restorative effects of probiotics in the context of early-life stress.en
dc.description.sponsorshipNational Health and Medical Research Council (APP1031688); Petre Foundation (scholarship); University of New South Wales Canberra (UNSW Research Excellence Award)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationCowan, C. S. M. and Richardson, R. 'Early-life stress leads to sex-dependent changes in pubertal timing in rats that are reversed by a probiotic formulation', Developmental Psychobiology, In Press, doi: 10.1002/dev.21765en
dc.identifier.doi10.1002/dev.21765
dc.identifier.endpage9en
dc.identifier.issn1098-2302
dc.identifier.journaltitleDevelopmental psychobiologyen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/7444
dc.language.isoenen
dc.publisherWileyen
dc.relation.projectinfo:eu-repo/grantAgreement/ARC/Discovery Projects/DP150104835/AU/Discovery Projects - Grant ID: DP150104835/en
dc.relation.urihttps://onlinelibrary.wiley.com/doi/abs/10.1002/dev.21765
dc.rights© 2018 Wiley Periodicals, Inc. This is the peer reviewed version of the following article: Cowan CSM, Richardson R. Early‐life stress leads to sex‐dependent changes in pubertal timing in rats that are reversed by a probiotic formulation. Developmental Psychobiology, 2018;00: 1–9, which has been published in final form at https://doi.org/10.1002/dev.21765. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."en
dc.subjectDevelopmenten
dc.subjectEarly‐life stressen
dc.subjectMaternal separationen
dc.subjectMicrobiota–gut–brain axisen
dc.subjectProbiotic treatmenten
dc.subjectPubertyen
dc.subjectRatsen
dc.subjectRodentsen
dc.titleEarly-life stress leads to sex-dependent changes in pubertal timing in rats that are reversed by a probiotic formulation.en
dc.typeArticle (peer-reviewed)en
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