Early-life stress leads to sex-dependent changes in pubertal timing in rats that are reversed by a probiotic formulation.

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dc.contributor.authorCowan, Caitlin S. M.
dc.contributor.authorRichardson, Rick
dc.contributor.funderAustralian Research Councilen
dc.contributor.funderNational Health and Medical Research Councilen
dc.contributor.funderPetre Foundationen
dc.contributor.funderUniversity of New South Walesen
dc.date.accessioned2019-02-06T09:57:59Z
dc.date.available2019-02-06T09:57:59Z
dc.date.issued2018-07-24
dc.date.updated2019-02-05T15:05:50Z
dc.description.abstractPuberty marks the beginning of a period of dramatic physical, hormonal, and social change. This instability has made adolescence infamous as a time of "storm and stress" and it is well-established that stress during adolescence can be particularly damaging. However, prior stress may also shape the adolescent experience. In the present series of experiments, we observed sex-specific effects of early-life maternal separation stress on the timing of puberty onset in the rat. Specifically, stressed females exhibited earlier pubertal onset compared to standard-reared females, whereas stressed males matured later than their standard-reared counterparts. Further, we demonstrated that a probiotic treatment restores the normative timing of puberty onset in rodents of both sexes. These results are in keeping with previous findings that probiotics reverse stress-induced changes in learned fear behaviors and stress hormone levels, highlighting the remarkable and wide-ranging restorative effects of probiotics in the context of early-life stress.en
dc.description.sponsorshipNational Health and Medical Research Council (APP1031688); Petre Foundation (scholarship); University of New South Wales Canberra (UNSW Research Excellence Award)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationCowan, C. S. M. and Richardson, R. 'Early-life stress leads to sex-dependent changes in pubertal timing in rats that are reversed by a probiotic formulation', Developmental Psychobiology, In Press, doi: 10.1002/dev.21765en
dc.identifier.doi10.1002/dev.21765
dc.identifier.endpage9en
dc.identifier.issn1098-2302
dc.identifier.journaltitleDevelopmental psychobiologyen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/7444
dc.language.isoenen
dc.publisherWileyen
dc.relation.projectinfo:eu-repo/grantAgreement/ARC/Discovery Projects/DP150104835/AU/Discovery Projects - Grant ID: DP150104835/en
dc.relation.urihttps://onlinelibrary.wiley.com/doi/abs/10.1002/dev.21765
dc.rights© 2018 Wiley Periodicals, Inc. This is the peer reviewed version of the following article: Cowan CSM, Richardson R. Early‐life stress leads to sex‐dependent changes in pubertal timing in rats that are reversed by a probiotic formulation. Developmental Psychobiology, 2018;00: 1–9, which has been published in final form at https://doi.org/10.1002/dev.21765. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."en
dc.subjectDevelopmenten
dc.subjectEarly‐life stressen
dc.subjectMaternal separationen
dc.subjectMicrobiota–gut–brain axisen
dc.subjectProbiotic treatmenten
dc.subjectPubertyen
dc.subjectRatsen
dc.subjectRodentsen
dc.titleEarly-life stress leads to sex-dependent changes in pubertal timing in rats that are reversed by a probiotic formulation.en
dc.typeArticle (peer-reviewed)en
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