Development and characterization of passivation methods for microneedle-based biosensors

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dc.contributor.authorBocchino, Andrea
dc.contributor.authorRodrigues Teixeira, Sofia
dc.contributor.authorIadanza, Simona
dc.contributor.authorMelnik, Eva
dc.contributor.authorKurzhals, Steffan
dc.contributor.authorMutinati, Giorgio C.
dc.contributor.authorO'Mahony, Conor
dc.contributor.funderHorizon 2020en
dc.date.accessioned2022-09-27T13:32:05Z
dc.date.available2022-09-27T13:32:05Z
dc.date.issued2022-07-15
dc.date.updated2022-09-27T11:50:18Z
dc.description.abstractMicroneedles (MN) are short, sharp structures that have the ability to painlessly pierce the stratum corneum, the outermost layer of the skin, and interface with the dermal interstitial fluid that lies beneath. Because the interstitial fluid is rich in biomarkers, microneedle-based biosensors have the potential to be used in a wide range of diagnostic applications. To act as an electrochemical sensor, the tip or the body of the MN must be functionalized, while the substrate areas are generally passivated to block any unwanted background interference that may occur outside of the skin. This work presents four different passivation techniques, based on the application of SiO2, polymethyl methacrylate (PMMA), an adhesive film, and varnish to the substrate areas. Optical, SEM and electrochemical measurements were performed to quantitatively assess the performance of each film. The data shows that whilst manual application of varnish provided the highest level of electrical isolation, the spin-coating of a 5 μm thick layer of PMMA is likely to provide the best combination of performance and manufacturability. Clinical Relevance— Substrate passivation techniques will improve the performance of microneedle-based non-invasive continuous monitoring systems.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationBocchino, A., Rodrigues Teixeira, S., Iadanza, S., Melnik, E., Kurzhals, S., Mutinati, G. C. and O'Mahony, C. (2022) 'Development and Characterization of Passivation Methods for Microneedle-based Biosensors', 44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE EMBC 2022), Glasgow, Scotland, UK, 11-15 July, pp. 1275-1278. doi: 10.1109/EMBC48229.2022.9871005en
dc.identifier.doi10.1109/EMBC48229.2022.9871005en
dc.identifier.eissn2694-0604
dc.identifier.endpage1278en
dc.identifier.isbn978-1-7281-2782-8
dc.identifier.startpage1275en
dc.identifier.urihttps://hdl.handle.net/10468/13675
dc.language.isoenen
dc.publisherIEEEen
dc.relation.ispartof44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE EMBC 2022)
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::RIA/825549/EU/Electronic smart patch system for wireless monitoring of molecular biomarkers for healthcare and well-being/ELSAHen
dc.relation.urihttps://doi.org/10.1109/EMBC48229.2022.9871455
dc.rights© 2022 The Authors. This work is licensed under a Creative Commons Attribution 3.0 License. For more information, see http://creativecommons.org/licenses/by/3.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/en
dc.subjectScanning electron microscopyen
dc.subjectBiomedical optical imagingen
dc.subjectOptical device fabricationen
dc.subjectNeedlesen
dc.subjectSkinen
dc.subjectOptical sensorsen
dc.subjectOptical reflectionen
dc.subjectBiosensing Techniquesen
dc.subjectNeedlesen
dc.subjectPolymethyl Methacrylateen
dc.subjectSilicon Dioxideen
dc.subjectSkinen
dc.titleDevelopment and characterization of passivation methods for microneedle-based biosensorsen
dc.typeConference itemen
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