Viromes of one year old infants reveal the impact of birth mode on microbiome diversity

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dc.contributor.authorMcCann, Angela
dc.contributor.authorRyan, Feargal J.
dc.contributor.authorStockdale, Stephen R.
dc.contributor.authorDalmasso, Marion
dc.contributor.authorBlake, Tony
dc.contributor.authorRyan, C. Anthony
dc.contributor.authorStanton, Catherine
dc.contributor.authorMills, Susan
dc.contributor.authorRoss, R. Paul
dc.contributor.authorHill, Colin
dc.contributor.funderIrish Research Council
dc.contributor.funderScience Foundation Ireland
dc.contributor.funderTeagasc
dc.contributor.funderEnterprise Ireland
dc.contributor.funderMarine Institute
dc.contributor.funderDepartment of Agriculture, Food and the Marine
dc.date.accessioned2018-09-24T12:36:56Z
dc.date.available2018-09-24T12:36:56Z
dc.date.issued2018
dc.description.abstractEstablishing a diverse gut microbiota after birth is being increasingly recognised as important for preventing illnesses later in life. It is well established that bacterial diversity rapidly increases post-partum; however, few studies have examined the infant gut virome/phageorne during this developmental period. We performed a metagenornic analysis of 20 infant faecal viromes at one year of age to determine whether spontaneous vaginal delivery (SVD) or caesarean section (CS) influenced viral composition. We find that birth mode results in distinctly different viral communities, with SVD infants having greater viral and bacteriophage diversity. We demonstrate that CrAssp age is acquired early in life, both in this cohort and two others, althoughno difference in birth mode is detected. A previous study has shown that bacterial OTU's (operational taxonomic units) identified in the same infants could not discriminate between birth mode at 12 months of age. Therefore, our results indicate that vertical transmission of viral communities from mother to child may play a role in shaping the early life microbiome, and that birth mode should be considered when studying the early life gut virome.en
dc.description.sponsorshipIrish Research Council (Biomarine Ingredients Ireland Ltd. via the IRC Enterprise Partnership Scheme); Teagasc (NutraMara programme MFFRI/07/01); Enterprise Ireland (SMART FOOD 13/F/411)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleide4694
dc.identifier.citationMcCann, A., Ryan, F. J., Stockdale, S. R., Dalmasso, M., Blake, T., Ryan, C. A., Stanton, C., Mills, S., Ross, P. R. and Hill, C. (2018) 'Viromes of one year old infants reveal the impact of birth mode on microbiome diversity', PeerJ, 6, e4694 (13pp). doi: 10.7717/peerj.4694en
dc.identifier.doi10.7717/peerj.4694
dc.identifier.endpage13
dc.identifier.issn2167-8359
dc.identifier.journaltitlePeerJen
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/10468/6871
dc.identifier.volume6
dc.language.isoenen
dc.publisherPeerJ, Incen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/
dc.relation.urihttps://peerj.com/articles/4694/
dc.rights© 2018, McCann et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectViromeen
dc.subjectInfanten
dc.subjectBirth modeen
dc.subjectBacteriophageen
dc.subjectMetagenomicsen
dc.subjectMicrobiomeen
dc.titleViromes of one year old infants reveal the impact of birth mode on microbiome diversityen
dc.typeArticle (peer-reviewed)en
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