In-hospital adverse drug reactions in hospitalised older adults - a systematic review

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dc.contributor.authorJennings, Emma L. M.
dc.contributor.authorMurphy, Kevin D.
dc.contributor.authorGallagher, Paul F.en
dc.contributor.authorO'Mahony, Denisen
dc.contributor.funderHorizon 2020
dc.date.accessioned2018-12-14T15:20:21Z
dc.date.available2018-12-14T15:20:21Z
dc.date.issued2018-09-17
dc.date.updated2018-12-13T08:07:12Z
dc.description.abstractBackground: Recent studies indicate that 1 in 4 older people experience an ADR in hospital. This systematic review [SR] aims to evaluate in-hospital ADRs in hospitalised older-adults in terms of incidence and prevalence, most commonly involved drug classes, severity, and consequences. Methods: Using PRISMA methodology [PROSPERO registration CRD42018079095], we systematically searched PubMed, Embase and Ebsco-CINAHL, Cochrane Library and library hosted academic sources, Google® scholar, and ‘grey’ literature. Search terms included aged, ADRs, hospitalized, multi-morbid, polypharmacy and hospital-acquired. A hand search of bibliography lists from relevant editorials and systematic reviews was conducted. We included studies of all languages and all dates up to and including the date of the final search [15/01/2018]. We included all studies that reported ADRs either as a primary or secondary outcome in patients aged ≥ 65 years who were hospitalised at time of ADR occurrence. Two researchers screened all papers for inclusion, risk of bias and data extraction. Results: Initial search yielded 1721 abstracts, 200 underwent full text screening. 60 papers were potentially suitable for inclusion; 48 papers contained pooled all-ages data, 12 papers reported directly on ADRs in our age cohort [2 papers reported the same data]. 11 studies were analysed, involving 4424 patients; 24% [1064] had experienced ADRs. 7 studies reported severity (n = 707); 31% [220] of ADRs were described as severe. 5 papers reported on post-ADR outcomes i.e. hospital length of stay [LOS, n = 3], death [n = 1] and functional decline [n = 1]. Frequency of culprit drug-groups by system were described in 6 papers [672 ADRs]; 43% [291] cardiovascular system, 17% [114] central nervous system, 16% [112] clotting pathways, 13% [90] anti-microbials. Conclusion: One in four over 65 years experience an ADR during hospitalisation, one third being severe, and almost half cardiovascular system drugs. Clinical outcomes associated with ADRs are generally poorly described in the literature.en
dc.description.abstractPoster presentationen
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationJennings, E., Murphy, K., Gallagher, P. and O’Mahony, D. (2018) '24In-Hospital Adverse Drug Reactions in Hospitalised Older Adults - A Systematic Review', 66th Annual & Scientific Meeting of the Irish Gerontological Society, Cavan, 27-29 September, in Age and Ageing, 47(suppl_5), pp. v13-v60. doi:10.1093/ageing/afy140.14en
dc.identifier.doi10.1093/ageing/afy140.14
dc.identifier.endpagev60en
dc.identifier.issn0002-0729
dc.identifier.issn1468-2834
dc.identifier.journaltitleAge and Ageingen
dc.identifier.startpagev13en
dc.identifier.urihttps://hdl.handle.net/10468/7223
dc.language.isoenen
dc.publisherOxford University Pressen
dc.relation.ispartof66th Annual & Scientific Meeting of the Irish Gerontological Society
dc.relation.urihttps://academic.oup.com/ageing/article/47/suppl_5/v13/5099153
dc.rights© The Author(s) 2018. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved.en
dc.subjectElderlyen
dc.subjectAdverse effects of medicationen
dc.subjectADRen
dc.subjectHospital-acquireden
dc.subjectGeriatric medicineen
dc.subjectGeriatric medicineen
dc.titleIn-hospital adverse drug reactions in hospitalised older adults - a systematic reviewen
dc.typeConference itemen
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