Comparative analysis of Faecalibacterium prausnitzii genomes shows a high level of genome plasticity and warrants separation into new species-level taxa
dc.contributor.author | Fitzgerald, Cormac Brian | |
dc.contributor.author | Shkoporov, Andrey N. | |
dc.contributor.author | Sutton, Thomas D. S. | |
dc.contributor.author | Chaplin, Andrei V. | |
dc.contributor.author | Velayudhan, Vimalkumar | |
dc.contributor.author | Ross, R. Paul | |
dc.contributor.author | Hill, Colin | |
dc.contributor.funder | Science Foundation Ireland | en |
dc.contributor.funder | European Regional Development Fund | en |
dc.contributor.funder | Janssen Biotech | en |
dc.date.accessioned | 2019-05-22T12:00:59Z | |
dc.date.available | 2019-05-22T12:00:59Z | |
dc.date.issued | 2018-12-14 | |
dc.description.abstract | Faecalibacterium prausnitzii is a ubiquitous member of the human gut microbiome, constituting up to 15% of the total bacteria in the human gut. Substantial evidence connects decreased levels of F. prausnitzii with the onset and progression of certain forms of inflammatory bowel disease, which has been attributed to its anti-inflammatory potential. Two phylogroups of F. prausnitzii have been identified, with a decrease in phylogroup I being a more sensitive marker of intestinal inflammation. Much of the genomic and physiological data available to date was collected using phylogroup II strains. Little analysis of F. prausnitzii genomes has been performed so far and genetic differences between phylogroups I and II are poorly understood. | en |
dc.description.status | Peer reviewed | en |
dc.description.version | Published Version | en |
dc.format.mimetype | application/pdf | en |
dc.identifier.articleid | 931 | en |
dc.identifier.citation | Fitzgerald, C.B., Shkoporov, A.N., Sutton, T.D., Chaplin, A.V., Velayudhan, V., Ross, R.P. and Hill, C., 2018. Comparative analysis of Faecalibacterium prausnitzii genomes shows a high level of genome plasticity and warrants separation into new species-level taxa. BMC genomics, 19(1), 931 (19pp) DOI: 10.1186/s12864-018-5313-6 | en |
dc.identifier.doi | 10.1186/s12864-018-5313-6 | en |
dc.identifier.endpage | 20 | en |
dc.identifier.issn | 1471-2164 | |
dc.identifier.issued | 1 | en |
dc.identifier.journaltitle | BMC Genomics | en |
dc.identifier.startpage | 1 | en |
dc.identifier.uri | https://hdl.handle.net/10468/7965 | |
dc.identifier.volume | 19 | en |
dc.language.iso | en | en |
dc.publisher | BMC part of Springer nature | en |
dc.relation.project | info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/ | en |
dc.relation.project | info:eu-repo/grantAgreement/SFI/SFI Spokes Programme/14/SP APC/B3032/IE/Gut Phageomics - Phage as diagnostics and/or therapeutics in IBD/ | en |
dc.relation.uri | https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-018-5313-6 | |
dc.rights | © 2018 The Author(s) | en |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en |
dc.subject | Faecalibacterium prausnitzii | en |
dc.subject | Ruminococcaceae | en |
dc.subject | Human gut microbiota | en |
dc.subject | IBD | en |
dc.subject | Genome shuffling | en |
dc.title | Comparative analysis of Faecalibacterium prausnitzii genomes shows a high level of genome plasticity and warrants separation into new species-level taxa | en |
dc.type | Article (peer-reviewed) | en |