Comparative analysis of Faecalibacterium prausnitzii genomes shows a high level of genome plasticity and warrants separation into new species-level taxa

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dc.contributor.authorFitzgerald, Cormac Brian
dc.contributor.authorShkoporov, Andrey N.
dc.contributor.authorSutton, Thomas D. S.
dc.contributor.authorChaplin, Andrei V.
dc.contributor.authorVelayudhan, Vimalkumar
dc.contributor.authorRoss, R. Paul
dc.contributor.authorHill, Colin
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderEuropean Regional Development Funden
dc.contributor.funderJanssen Biotechen
dc.date.accessioned2019-05-22T12:00:59Z
dc.date.available2019-05-22T12:00:59Z
dc.date.issued2018-12-14
dc.description.abstractFaecalibacterium prausnitzii is a ubiquitous member of the human gut microbiome, constituting up to 15% of the total bacteria in the human gut. Substantial evidence connects decreased levels of F. prausnitzii with the onset and progression of certain forms of inflammatory bowel disease, which has been attributed to its anti-inflammatory potential. Two phylogroups of F. prausnitzii have been identified, with a decrease in phylogroup I being a more sensitive marker of intestinal inflammation. Much of the genomic and physiological data available to date was collected using phylogroup II strains. Little analysis of F. prausnitzii genomes has been performed so far and genetic differences between phylogroups I and II are poorly understood.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid931en
dc.identifier.citationFitzgerald, C.B., Shkoporov, A.N., Sutton, T.D., Chaplin, A.V., Velayudhan, V., Ross, R.P. and Hill, C., 2018. Comparative analysis of Faecalibacterium prausnitzii genomes shows a high level of genome plasticity and warrants separation into new species-level taxa. BMC genomics, 19(1), 931 (19pp) DOI: 10.1186/s12864-018-5313-6en
dc.identifier.doi10.1186/s12864-018-5313-6en
dc.identifier.endpage20en
dc.identifier.issn1471-2164
dc.identifier.issued1en
dc.identifier.journaltitleBMC Genomicsen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/7965
dc.identifier.volume19en
dc.language.isoenen
dc.publisherBMC part of Springer natureen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Spokes Programme/14/SP APC/B3032/IE/Gut Phageomics - Phage as diagnostics and/or therapeutics in IBD/en
dc.relation.urihttps://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-018-5313-6
dc.rights© 2018 The Author(s)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectFaecalibacterium prausnitziien
dc.subjectRuminococcaceaeen
dc.subjectHuman gut microbiotaen
dc.subjectIBDen
dc.subjectGenome shufflingen
dc.titleComparative analysis of Faecalibacterium prausnitzii genomes shows a high level of genome plasticity and warrants separation into new species-level taxaen
dc.typeArticle (peer-reviewed)en
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