Calcium signaling in oomycetes: an evolutionary perspective
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Date
2016-04-05
Authors
Zheng, Limian
Mackrill, John J.
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Frontiers Media
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Abstract
Oomycetes are a family of eukaryotic microbes that superficially resemble fungi, but which are phylogenetically distinct from them. These organisms cause major global economic losses to agriculture and fisheries, with representative pathogens being Phytophthora infestans, the cause of late potato blight and Saprolegnia diclina, the instigator of “cotton molds” in fish. As in all eukaryotes, cytoplasmic Ca2+ is a key second messenger in oomycetes, regulating life-cycle transitions, controlling motility and chemotaxis and, in excess, leading to cell-death. Despite this, little is known about the molecular mechanisms regulating cytoplasmic Ca2+ concentrations in these organisms. Consequently, this review analyzed the presence of candidate calcium channels encoded within the nine oomycete genomes that are currently available. This revealed key differences between oomycetes and other eukaryotes, in particular the expansion and loss of different channel families, and the presence of a phylum-specific group of proteins, termed the polycystic kidney disease tandem ryanodine receptor domain (PKDRR) channels.
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Keywords
Calcium channels , Oomycetes , Evolution , Phylogenetics , Inositol 1,4,5-trisphosphate receptors , Ryanodine receptors
Citation
Zheng, L. and Mackrill, J. J. (2016) 'Calcium Signaling in Oomycetes: An Evolutionary Perspective', Frontiers in Physiology, 7(123). doi:10.3389/fphys.2016.00123
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© 2016 Zheng and Mackrill. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.