Vitamin D binding protein genotype is associated with serum 25-hydroxyvitamin D and PTH concentrations, as well as bone health in children and adolescents in Finland

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dc.contributor.authorPekkinen, Minna
dc.contributor.authorSaarnio, Elisa
dc.contributor.authorViljakainen, Heli T.
dc.contributor.authorKokkonen, Elina
dc.contributor.authorJakobsen, Jette
dc.contributor.authorCashman, Kevin D.en
dc.contributor.authorMakitie, Outi
dc.contributor.authorLamberg-Allardt, Christel
dc.contributor.funderFoundation for Pediatric Research, Finland
dc.contributor.funderYrjö Jahnsson Foundation, Finland
dc.contributor.funderAcademy of Finland
dc.contributor.funderHelsinki University Hospital, Finland
dc.contributor.funderSigrid Juselius Foundation, Finland
dc.contributor.funderElla and Georg Ehrnrooth Foundation, Finland
dc.contributor.funderUniversity of Helsinki Research Foundation, Finland
dc.contributor.funderMaud Kuistila Memorial Foundation, Finland
dc.contributor.funderFolkhälsan Research Foundation, Finland
dc.contributor.funderUniversity of Tampere, Finland
dc.contributor.funderFinnish Graduate School on Applied Biosciences, Finland
dc.date.accessioned2016-02-17T11:44:41Z
dc.date.available2016-02-17T11:44:41Z
dc.date.issued2014
dc.description.abstractVitamin D binding protein (DBP)/group-specific component (Gc), correlates positively with serum vitamin D metabolites, and phenotype influences serum 25-hydroxyvitamin D (S-25(OH)D) concentration. The protein isoform has been associated with decreased bone mineral density (BMD) and increased fracture risk. We examined the role of GC genotypes in S-25(OH)D status and BMD in 231 Finnish children and adolescents aged 7-19 yr. BMD was measured with DXA from lumbar spine (LS), total hip, and whole body, and for 175 subjects, radial volumetric BMD was measured with pQCT. Background characteristic and total dietary intakes of vitamin D and calcium were collected. The concentrations of 25(OH)D, parathyroid hormone (PTH), calcium and other markers of calcium homeostasis were determined from blood and urine. Genotyping was based on single-nucleotide polymorphism (rs4588) in the GC gene. The genotype distribution was: GC 1/1 68%, GC 1/2 26% and GC 2/2 6%. A significant difference emerged in 25(OH)D and PTH concentrations between the genotypes, (p = 0.001 and 0.028 respectively, ANCOVA). There was also a linear trend in: Gc 2/2 had the lowest 25(OH) D and PTH concentrations (p = 0.025 and 0.012, respectively). Total hip bone mineral content was associated with GC genotype (BMC) (p = 0.05, ANCOVA) in boys. In regression analysis, after adjusting for relevant covariates, GC genotype was associated with LS BMC and strength and strain index (SSI) Z-score in both genders, and LS BMD in boys. In conclusion, the present study demonstrates the association between GC genotypes and S-25(OH)D and PTH concentrations. The results show the influence of DBP genetic variation on bone mass accrual in adolescence.en
dc.description.sponsorshipHelsinki University Hospital (Research Funds); University of Tampere, Finland (National Doctoral Programme of Musculoskeletal Disorders and Biomaterials)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleide87292
dc.identifier.citationPekkinen M, Saarnio E, Viljakainen HT, Kokkonen E, Jakobsen J, Cashman K, et al. (2014) Vitamin D Binding Protein Genotype Is Associated with Serum 25-Hydroxyvitamin D and PTH Concentrations, as Well as Bone Health in Children and Adolescents in Finland. PLoS ONE 9(1): e87292. doi:10.1371/journal.pone.0087292
dc.identifier.doi10.1371/journal.pone.0087292
dc.identifier.issn1932-6203
dc.identifier.issued1en
dc.identifier.journaltitlePLOS ONEen
dc.identifier.urihttps://hdl.handle.net/10468/2344
dc.identifier.volume9en
dc.language.isoenen
dc.publisherPublic Library of Scienceen
dc.rights© 2015 Pekkinen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are crediteden
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectGroup-specific componenten
dc.subjectMineral densityen
dc.subjectGc globulinen
dc.subjectPlasma concentrationsen
dc.subjectFracture risken
dc.subjectGeneen
dc.subjectOsteoporosisen
dc.subjectPolymorphismen
dc.subjectPhenotypeen
dc.subjectGrowthen
dc.titleVitamin D binding protein genotype is associated with serum 25-hydroxyvitamin D and PTH concentrations, as well as bone health in children and adolescents in Finlanden
dc.typeArticle (peer-reviewed)en
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