Effect of investigation intensity and treatment differences on prostate cancer survivor's physical symptoms, psychological well-being and health-related quality of life: a two country cross-sectional study.
| dc.contributor.author | Gavin, Anna T. | |
| dc.contributor.author | Donnelly, David | |
| dc.contributor.author | Donnelly, Conan | |
| dc.contributor.author | Drummond, Frances J. | |
| dc.contributor.author | Morgan, Eileen | |
| dc.contributor.author | Gormley, Gerard J. | |
| dc.contributor.author | Sharp, Linda | |
| dc.contributor.funder | Public Health Agency | en |
| dc.contributor.funder | Prostate Cancer UK | en |
| dc.contributor.funder | Health Research Board | en |
| dc.contributor.funder | Northern Ireland Ireland Cancer Registry | en |
| dc.contributor.funder | Research and Development Office Northern Ireland | |
| dc.contributor.funder | National Cancer Control Programme, Ireland | en |
| dc.date.accessioned | 2017-01-04T14:34:02Z | |
| dc.date.available | 2017-01-04T14:34:02Z | |
| dc.date.issued | 2016-12-19 | |
| dc.description.abstract | Aim: To investigate effects on men's health and well-being of higher prostate cancer (PCa) investigation and treatment levels in similar populations. Participants: PCa survivors in Ireland where the Republic of Ireland (RoI) has a 50% higher PCa incidence than Northern Ireland (NI). Method: A cross-sectional postal questionnaire was sent to PCa survivors 2–18 years post-treatment, seeking information about current physical effects of treatment, health-related quality of life (HRQoL; EORTC QLQ-C30; EQ-5D-5L) and psychological well-being (21 question version of the Depression, Anxiety and Stress Scale, DASS-21). Outcomes in RoI and NI survivors were compared, stratifying into ‘late disease’ (stage III/IV and any Gleason grade (GG) at diagnosis) and ‘early disease’ (stage I/II and GG 2–7). Responses were weighted by age, jurisdiction and time since diagnosis. Between-country differences were investigated using multivariate logistic and linear regression. Results: 3348 men responded (RoI n=2567; NI n=781; reflecting population sizes, response rate 54%). RoI responders were younger; less often had comorbidities (45% vs 38%); were more likely to present asymptomatically (66%; 41%) or with early disease (56%; 35%); and less often currently used androgen deprivation therapy (ADT; 2%; 28%). Current prevalence of incontinence (16%) and impotence (56% early disease, 67% late disease) did not differ between RoI and NI. In early disease, only current bowel problems (RoI 12%; NI 21%) differed significantly in multivariate analysis. In late disease, NI men reported significantly higher levels of gynaecomastia (23% vs 9%) and hot flashes(41% vs 19%), but when ADT users were analysed separately, differences disappeared. For HRQoL, in multivariate analysis, only pain (early disease: RoI 11.1, NI 19.4) and financial difficulties (late disease: RoI 10.4, NI 7.9) differed significantly between countries. There were no significant between-country differences in DASS-21 or index ED-5D-5L score. Conclusions: Treatment side effects were commonly reported and increased PCa detection in RoI has left more men with these side effects. We recommended that men be offered a PSA test only after informed discussion. | en |
| dc.description.sponsorship | Northern Ireland Ireland Cancer Registry (funded by the Public Health Agency for Northern Ireland); Prostate cancer UK (N109–03 and NI-PG13–01); Research and Development Office Northern Ireland; Health Research Board (HRA_HSR/2010/17); National Cancer Control Programme, Ireland | en |
| dc.description.status | Peer reviewed | en |
| dc.description.version | Published Version | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.citation | Gavin, A. T., Donnelly, D., Donnelly, C., Drummond, F. J., Morgan, E., Gormley, G. J. and Sharp, L. (2016) 'Effect of investigation intensity and treatment differences on prostate cancer survivor's physical symptoms, psychological well-being and health-related quality of life: a two country cross-sectional study', BMJ Open, 6(12), e012952 (10 pp). doi: 10.1136/bmjopen-2016-012952 | en |
| dc.identifier.doi | 10.1136/bmjopen-2016-012952 | |
| dc.identifier.endpage | e012952-10 | en |
| dc.identifier.issn | 2044-6055 | |
| dc.identifier.issued | 12 | en |
| dc.identifier.journaltitle | BMJ Open | en |
| dc.identifier.startpage | e012952-1 | en |
| dc.identifier.uri | https://hdl.handle.net/10468/3421 | |
| dc.identifier.volume | 6 | en |
| dc.language.iso | en | en |
| dc.publisher | BMJ Publishing Group | en |
| dc.rights | © 2016, The Authurs. Licence BMJ Publishing Group. This article was published in BMJ Open following peer review and can also be viewed on the journal’s website at http://bmjopen.bmj.com. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ | en |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | en |
| dc.subject | Prostate cancer | en |
| dc.subject | PCa detection | en |
| dc.subject | PCa | en |
| dc.subject | Treatment side effects | en |
| dc.title | Effect of investigation intensity and treatment differences on prostate cancer survivor's physical symptoms, psychological well-being and health-related quality of life: a two country cross-sectional study. | en |
| dc.type | Article (peer-reviewed) | en |
