Structural investigation of polysaccharides extracted from four Bifidobacterium breve strains

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dc.contributor.authorVinogradov, Evgeny
dc.contributor.authorSadovskaya, Irina
dc.contributor.authorMcDonnell, Brian
dc.contributor.authorCoughlan, Keith
dc.contributor.authorBottacini, Francesca
dc.contributor.authorvan Sinderen, Douwe
dc.contributor.funderScience Foundation Ireland(SFI)
dc.contributor.funderMunster Technological University
dc.contributor.funderEuropean Regional Development Fund
dc.date.accessioned2026-05-22T09:50:03Z
dc.date.available2026-05-22T09:50:03Z
dc.date.issued2026-05-05
dc.description.abstractBifidobacterium breve is a common component of the human gut microbiota, particularly in infancy. Its surface-exposed polysaccharides may be important for its purported health-promoting activities and may serve various functions such as immune evasion and modulation, environmental stress protection, or carbohydrate substrate provision for other gut commensals. In the present work, we extracted and analysed polysaccharides from four strains of B. breve. Their chemical structure was established by 2D NMR spectroscopy and methylation analysis. Most analysed strains produced several distinct saccharidic structures, some of which contained common rhamnan substructures. The uncovered complexity and multitude of polysaccharides produced by representatives of a single species of the Bifidobacterium genus illustrates clear strain specificity which may underpin probiotic and other properties of this group of human gut commensals.en
dc.description.sponsorshipScience Foundation Ireland (now Research Ireland) under grant numbers 12/RC/2273-P1 and 12/RC/2273-P2. MTU TU RISE Research Scholarships, co-financed by MTU and the Government of Ireland and the European Union through ERDF, Southern, Regional, Eastern & Midland Regional Programme 2021-27 and the Northern and Western programme 2021-27.
dc.description.versionPublished Version
dc.format.extent10
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid109946
dc.identifier.authororcidVinogradov, Evgeny
dc.identifier.authororcidSadovskaya, Irina
dc.identifier.authororcidMcDonnell, Brian§0000-0003-1704-8759
dc.identifier.authororcidCoughlan, Keith
dc.identifier.authororcidBottacini, Francesca
dc.identifier.authororcidvan Sinderen, Douwe§0000-0003-1823-7957
dc.identifier.citationVinogradov, E, Sadovskaya, I, McDonnell, B, Coughlan, K, Bottacini, F & van Sinderen, D 2026, 'Structural investigation of polysaccharides extracted from four Bifidobacterium breve strains', Carbohydrate Research, vol. 566, 109946, pp. 1-10. https://doi.org/10.1016/j.carres.2026.109946
dc.identifier.doi10.1016/j.carres.2026.109946
dc.identifier.endpage10
dc.identifier.issn0008-6215
dc.identifier.journaltitleCarbohydrate Research
dc.identifier.otherORCID: /0000-0003-1704-8759/work/215853634
dc.identifier.otherORCID: /0000-0003-1823-7957/work/217137295
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/10468/18822
dc.identifier.volume566
dc.language.isoen
dc.publisherElsevier Ltd
dc.relation.urihttps://www.scopus.com/pages/publications/105037432703
dc.rights© 2026, the Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ ).
dc.rights.accessrightsopen access
dc.rights.licensenameAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.statusPeer reviewed
dc.subject2D NMR
dc.subjectGut microbiota
dc.subjectMicrobe-host interaction
dc.subjectPolysaccharide
dc.subjectProbiotic
dc.subject[Microbiology]
dc.titleStructural investigation of polysaccharides extracted from four Bifidobacterium breve strainsen
dc.typeArticle (peer-reviewed)
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