The microbiome and cancer

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dc.availability.bitstreamembargoed
dc.check.date2022-09-30
dc.contributor.advisorO'Toole, Paul W.en
dc.contributor.advisorShanahan, Fergusen
dc.contributor.advisorHand, Colletteen
dc.contributor.authorBarrett, Maurice P. J.
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderHealth Research Boarden
dc.date.accessioned2021-09-23T13:17:49Z
dc.date.available2021-09-23T13:17:49Z
dc.date.issued2021-06-04
dc.date.submitted2021-06-04
dc.description.abstractCancers arise through the process of somatic evolution fuelled by the inception of somatic mutations. We lack a complete understanding of the sources of these somatic mutations. Humans host a vast repertoire of microbes collectively known as the microbiota. The microbiota plays a role in altering the tumour microenvironment and proliferation. In addition, microbes have been shown to elicit DNA damage which provides the substrate for somatic mutations. An understanding of microbiota-driven mutational mechanism would contribute to a more complete understanding of the origins of the cancer genome. Here we review the modes by which microbes stimulate DNA damage and the effect of these phenomena upon the cancer genomic architecture, specifically in the form of mutational spectra and mutational signatures.en
dc.description.statusNot peer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationBarrett, M. P. J. 2021. The microbiome and cancer. PhD Thesis, University College Cork.en
dc.identifier.endpage387en
dc.identifier.urihttps://hdl.handle.net/10468/11990
dc.language.isoenen
dc.publisherUniversity College Corken
dc.rights© 2021, Maurice Barrett.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectMicrobiomeen
dc.subjectMicrobiotaen
dc.subjectCanceren
dc.titleThe microbiome and canceren
dc.typeDoctoral thesisen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnamePhD - Doctor of Philosophyen
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