Feasibility of low-dose CT with model-based iterative image reconstruction in follow-up of patients with testicular cancer.

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dc.contributor.authorMurphy, Kevin P.
dc.contributor.authorCrush, Lee
dc.contributor.authorO'Neill, Siobhán B.
dc.contributor.authorFoody, James
dc.contributor.authorBreen, Micheál
dc.contributor.authorBrady, Adrian
dc.contributor.authorKelly, Paul J.
dc.contributor.authorPower, Derek G.
dc.contributor.authorSweeney, Paul
dc.contributor.authorBye, Jackie
dc.contributor.authorO'Connor, Owen J.
dc.contributor.authorMaher, Michael M.
dc.contributor.authorO'Regan, Kevin N.
dc.date.accessioned2018-04-24T15:54:36Z
dc.date.available2018-04-24T15:54:36Z
dc.date.issued2016-02-16
dc.date.updated2018-04-23T16:23:03Z
dc.description.abstractPurpose: We examine the performance of pure model-based iterative reconstruction with reduced-dose CT in follow-up of patients with early-stage testicular cancer. Methods: Sixteen patients (mean age 35.6 ± 7.4 years) with stage I or II testicular cancer underwent conventional dose (CD) and low-dose (LD) CT acquisition during CT surveillance. LD data was reconstructed with model-based iterative reconstruction (LD–MBIR). Datasets were objectively and subjectively analysed at 8 anatomical levels. Two blinded clinical reads were compared to gold-standard assessment for diagnostic accuracy. Results: Mean radiation dose reduction of 67.1% was recorded. Mean dose measurements for LD–MBIR were: thorax – 66 ± 11 mGy cm (DLP), 1.0 ± 0.2 mSv (ED), 2.0 ± 0.4 mGy (SSDE); abdominopelvic – 128 ± 38 mGy cm (DLP), 1.9 ± 0.6 mSv (ED), 3.0 ± 0.6 mGy (SSDE). Objective noise and signal-to-noise ratio values were comparable between the CD and LD–MBIR images. LD–MBIR images were superior (p < 0.001) with regard to subjective noise, streak artefact, 2-plane contrast resolution, 2-plane spatial resolution and diagnostic acceptability. All patients were correctly categorised as positive, indeterminate or negative for metastatic disease by 2 readers on LD–MBIR and CD datasets. Conclusions: MBIR facilitated a 67% reduction in radiation dose whilst producing images that were comparable or superior to conventional dose studies without loss of diagnostic utility.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMurphy, K. P., Crush, L., O’Neill, S. B., Foody, J., Breen, M., Brady, A., Kelly, P. J., Power, D. G., Sweeney, P., Bye, J., O’Connor, O. J., Maher, M. M. and O’Regan, K. N. (2016) 'Feasibility of low-dose CT with model-based iterative image reconstruction in follow-up of patients with testicular cancer', European Journal of Radiology Open, 3, pp. 38-45. doi: 10.1016/j.ejro.2016.01.002en
dc.identifier.doi10.1016/j.ejro.2016.01.002
dc.identifier.endpage45en
dc.identifier.issn2352-0477
dc.identifier.issued3en
dc.identifier.journaltitleEuropean Journal of Radiologyen
dc.identifier.startpage38en
dc.identifier.urihttps://hdl.handle.net/10468/5869
dc.identifier.volume16en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urihttp://www.sciencedirect.com/science/article/pii/S2352047716300028
dc.rights© 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectRadiation doseen
dc.subjectComputed tomographyen
dc.subjectLow dose CTen
dc.subjectTesticular canceren
dc.subjectLow-dose computed tomographyen
dc.subjectIterative reconstructionen
dc.subjectModel-based iterative reconstructionen
dc.titleFeasibility of low-dose CT with model-based iterative image reconstruction in follow-up of patients with testicular cancer.en
dc.typeArticle (peer-reviewed)en
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