Deprescribing in cognitively vulnerable older people: development and validation of STOPPCog criteria

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dc.check.date2026-02-04en
dc.check.infoAccess to this article is restricted until 12 months after publication by request of the publisheren
dc.contributor.authorMcGettigan, Siobhanen
dc.contributor.authorCurtin, Denisen
dc.contributor.authorO’Mahony, Denisen
dc.date.accessioned2025-03-26T09:11:10Z
dc.date.available2025-03-26T09:11:10Z
dc.date.issued2025-02-04en
dc.description.abstractObjective: To validate STOPPCog, a list of explicit criteria for potentially inappropriate medication use in cognitively vulnerable older adults. Design: A Delphi consensus survey of an expert panel comprising academic geriatricians, old age psychiatrists, general practitioners, and clinical pharmacists.Setting: Ireland. Subjects: Nine panellists. Methods: STOPPCog criteria were initially created by the authors based on clinical experience and literature appraisal. Criteria were organised according to drug/drug class. Using Delphi consensus methodology, panellists ranked their agreement with each criterion on a 5-point Likert scale and provided written feedback. Criteria with a median value of 1 or 2 (strongly agree/agree) and a 25th centile value of ≤2 were included in the final list. Results: All panellists completed two Delphi consensus validation rounds. Twenty-five criteria were proposed initially, twenty were accepted. One criterion was rejected (multi-vitamin supplements), and four criteria were rephrased (two of these were combined to one criterion for greater clarity). The final list comprised 23 criteria that are arranged in six subgroups i.e. (i) drugs with anticholinergic properties taken daily; (ii) drugs with sedative properties taken daily; (iii) drugs that may exacerbate psychotic symptoms in patients with alpha-synuclein pathology; (iv) drugs used for chronic pain; (v) drugs without proven efficacy for dementia taken daily; (vi) drugs that are of no proven benefit in advanced stage dementia i.e. clinical dementia rating of 3.0 where palliation may be appropriate. Conclusion: STOPPCog comprises 23 criteria relating to medications that are potentially inappropriate in cognitively vulnerable older adults. STOPPCog may assist physicians in deprescribing medications in this patient population.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleidafaf014en
dc.identifier.citationMcGettigan, S., Curtin, D. and O’Mahony, D. (2025) 'Deprescribing in cognitively vulnerable older people: development and validation of STOPPCog criteria', Age and Ageing, 54(2), afaf014 (7pp). https://doi.org/10.1093/ageing/afaf014en
dc.identifier.doihttps://doi.org/10.1093/ageing/afaf014en
dc.identifier.eissn1468-2834en
dc.identifier.endpage7en
dc.identifier.issn0002-0729en
dc.identifier.issued2en
dc.identifier.journaltitleAge and Ageingen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/17197
dc.identifier.volume54en
dc.language.isoenen
dc.publisherOxford University Pressen
dc.relation.ispartofAge and Ageingen
dc.rights© 2025, the Authors. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved.en
dc.subjectPolypharmacyen
dc.subjectDeprescribingen
dc.subjectCognitionen
dc.subjectDementiaen
dc.subjectPotentially inappropriate medication (PIM)en
dc.subjectOlder peopleen
dc.titleDeprescribing in cognitively vulnerable older people: development and validation of STOPPCog criteriaen
dc.typeArticle (peer-reviewed)en
dc.typejournal-articleen
oaire.citation.issue2en
oaire.citation.volume54en
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