Pilot-scale ceramic membrane filtration of skim milk for the production of a 'humanised' protein base ingredient for infant milk formula

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dc.contributor.authorMcCarthy, Noel A.
dc.contributor.authorWijayanti, Heni B.
dc.contributor.authorCrowley, Shane V.
dc.contributor.authorO'Mahony, James A.
dc.contributor.authorFenelon, Mark A.
dc.contributor.funderDepartment of Agriculture, Food and the Marineen
dc.date.accessioned2017-08-31T12:14:29Z
dc.date.available2017-08-31T12:14:29Z
dc.date.issued2017-05-08
dc.date.updated2017-08-31T11:07:53Z
dc.description.abstractThe protein composition of bovine skim milk was modified using pilot scale membrane filtration to produce a whey protein-dominant ingredient with a casein profile closer to human milk. Bovine skim milk was processed at low (8.9 °C) or high (50 °C) temperature using ceramic microfiltration (MF) membranes (0.1 μm mean pore diameter). The resulting permeate stream was concentrated using polyethersulfone ultrafiltration (UF) membranes (10 kDa cut-off). The protein profile of MF and UF retentate streams were determined using reversed phase-high performance liquid chromatography and polyacrylamide gel electrophoresis. Permeate from the cold MF process (8.9 °C) had a casein:whey protein ratio of ∼35:65 with no αS- or κ-casein present, compared with a casein:whey protein ratio of ∼10:90 at 50 °C. This study has demonstrated the application of cold membrane filtration (8.9 °C) at pilot scale to produce a dairy ingredient with a protein profile closer to that of human milk.en
dc.description.sponsorshipDepartment of Agriculture, Food and the Marine (Project Reference Number 10RDTMFRC706)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMcCarthy, N. A., Wijayanti, H. B., Crowley, S. V., O'Mahony, J. A., and Fenelon, M. A. (2017) 'Pilot-scale ceramic membrane filtration of skim milk for the production of a 'humanised' protein base ingredient for infant milk formula', International Dairy Journal, 73, pp. 57-62. doi:10.1016/j.idairyj.2017.04.010en
dc.identifier.doi10.1016/j.idairyj.2017.04.010
dc.identifier.endpage62en
dc.identifier.issn0958-6946
dc.identifier.journaltitleInternational Dairy Journalen
dc.identifier.startpage57en
dc.identifier.urihttps://hdl.handle.net/10468/4596
dc.identifier.volume73en
dc.language.isoenen
dc.publisherElsevier Ltden
dc.rights© 2017, Published by Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectProteinen
dc.subjectHuman milken
dc.subjectFiltrationen
dc.titlePilot-scale ceramic membrane filtration of skim milk for the production of a 'humanised' protein base ingredient for infant milk formulaen
dc.typeArticle (peer-reviewed)en
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