The effect of exercise interventions on inflammatory biomarkers in healthy, physically inactive subjects: a systematic review

Simple item page
dc.contributor.authorCronin, Owen
dc.contributor.authorKeohane, David M.
dc.contributor.authorMolloy, Michael G.
dc.contributor.authorShanahan, Fergus
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderIrish Centre for Arthritis Research and Education (ICARE)en
dc.date.accessioned2017-06-23T10:56:18Z
dc.date.available2017-06-23T10:56:18Z
dc.date.issued2017-05-02
dc.description.abstractBackground: Increases in physical activity ameliorate low-grade systemic inflammation in disease populations such as type 2 diabetes mellitus and coronary artery disease. The effects of aerobic and resistance training (RT) on inflammatory biomarker profiles in non-disease, physically inactive individuals are unknown. Methods: A systematic review of randomized controlled trials measuring the effect of aerobic and resistance exercise on pro-inflammatory biomarkers in healthy, inactive adult populations was conducted. The available peer-reviewed literature was searched from January 1990 to June 2016 using the electronic databases PubMed and Scopus. A narrative synthesis of review findings was constructed with discussion of the impact of aerobic, resistance and combined training on C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-8, interleukin-1β and tumour necrosis factor-α. Results: The initial search revealed 1596 potentially relevant studies. Application of the study eligibility criteria led to the full-text review of 54 articles with 11 studies deemed suitable for inclusion. Review of related articles and the reference lists of the 54 full-text articles led to the inclusion of 2 additional studies. The review revealed inconsistent findings relating to the effect of aerobic training and RT on CRP and IL-6. Studies of older-aged adults (>65 years old) demonstrated the greatest and most consistent reduction in inflammatory biomarkers post-training intervention. Conclusions: A paucity of evidence exists relating to the effect of exercise training on inflammatory markers in non-disease, physically inactive adults. The available evidence suggests potential for the greatest benefit to be seen in older populations and with higher intensity aerobic exercise.en
dc.description.sponsorshipScience Foundation Ireland (SFI centre grant to the Alimentary Pharamabiotic Centre (APC) Microbiome Institute (grant no. SFI/12/RC/2273)); Irish Centre for Arthritis Research and Education (ICARE)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationCronin, O., Keohane, D.M., Molloy, M. G. and Shanahan, F., (2017) ‘The effect of exercise interventions on inflammatory biomarkers in healthy, physically inactive subjects: a systematic review’, QJM, 110(10), pp. 629-637. doi: 10.1093/qjmed/hcx091en
dc.identifier.doi10.1093/qjmed/hcx091
dc.identifier.endpage637
dc.identifier.issn1460-2725
dc.identifier.issued10
dc.identifier.journaltitleQJM: An International Journal of Medicineen
dc.identifier.startpage629
dc.identifier.urihttps://hdl.handle.net/10468/4182
dc.identifier.volume110
dc.language.isoenen
dc.publisherOxford University Pressen
dc.rights© The Author 2017. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. This is a pre-copyedited, author-produced version of an article accepted for publication in QJM following peer review. The version of record is available online at: https://doi.org/10.1093/qjmed/hcx091en
dc.subjectPhysical activityen
dc.subjectCoronary arteriosclerosisen
dc.subjectAerobic exerciseen
dc.subjectInflammatory markersen
dc.subjectInflammationen
dc.subjectDiabetes mellitusen
dc.subjectType 2en
dc.subjectExerciseen
dc.subjectAdult biological markersen
dc.subjectInterleukin-8en
dc.subjectInterleukinsen
dc.subjectC-reactive proteinen
dc.subjectInterleukin-6en
dc.subjectExerciseen
dc.subjectResistiveen
dc.subjectTumor necrosisen
dc.subjectNarrative discourseen
dc.subjectStrength trainingen
dc.titleThe effect of exercise interventions on inflammatory biomarkers in healthy, physically inactive subjects: a systematic reviewen
dc.typeArticle (peer-reviewed)en
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
2931.pdf
Size:
644.27 KB
Format:
Adobe Portable Document Format
Description:
Accepted version
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
APC Microbiome Ireland - Journal Articles
Medicine - Journal Articles