Flow injection chemiluminescence determination of isoniazid using luminol and silver nanoparticles
dc.contributor.author | Haghighi, Behzad | |
dc.contributor.author | Bozorgzadeh, Somayyeh | |
dc.contributor.funder | Institute for Advanced Studies in Basic Sciences (IASBS), Iran | en |
dc.date.accessioned | 2022-08-31T09:12:27Z | |
dc.date.available | 2022-08-31T09:12:27Z | |
dc.date.issued | 2010-12-01 | |
dc.date.updated | 2022-08-31T09:09:06Z | |
dc.description.abstract | The effect of silver colloidal nanoparticles (AgNPs) on the luminol-isoniazid system was investigated. It was found that AgNPs could act as a nanocatalyst on the luminol-isoniazid system to generate chemiluminescence (CL). The CL emission spectrum of the luminol-isoniazid-AgNPs system showed a peak with a maximum at 425 nm. It was suggested that the luminophor species was the excited state 3-aminophthalate. The reduction of dissolved O2 to H2O2 by isoniazid and decomposition of H2O2 to the oxygen-related radicals were attributed to the catalytic effect of AgNPs. Under optimized conditions, the CL signal intensity was linear with the isoniazid concentration in the range of 10-1000 ng mL- 1, with the correlation coefficient of 0.9996. The limit of detection was 2.7 ng mL- 1 isoniazid. The relative standard deviations for seven repeated measurements of 60 and 200 ng mL- 1 isoniazid were 1.4 and 2.4%, respectively. The effect of potent interfering compounds on the CL signal intensity of the proposed luminol-isoniazid-AgNPs system was investigated. The proposed method was successfully applied to the determination of isoniazid in a pharmaceutical sample. | en |
dc.description.status | Peer reviewed | en |
dc.description.version | Accepted Version | en |
dc.format.mimetype | application/pdf | en |
dc.identifier.citation | Haghighi, B. and Bozorgzadeh, S. (2010) 'Flow injection chemiluminescence determination of isoniazid using luminol and silver nanoparticles', Microchemical Journal, 95 (2), pp. 192-197. doi: 10.1016/j.microc.2009.11.012 | en |
dc.identifier.doi | 10.1016/j.microc.2009.11.012 | en |
dc.identifier.endpage | 197 | en |
dc.identifier.issn | 0026-265X | |
dc.identifier.issued | 2 | en |
dc.identifier.journaltitle | Microchemical Journal | en |
dc.identifier.startpage | 192 | en |
dc.identifier.uri | https://hdl.handle.net/10468/13519 | |
dc.identifier.volume | 95 | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.relation.uri | https://doi.org/10.1016/j.microc.2009.11.012 | |
dc.rights | © 2010 Elsevier B. V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ | en |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | en |
dc.subject | Chemiluminescence | en |
dc.subject | Flow injection analysis | en |
dc.subject | Isoniazid | en |
dc.subject | Luminol | en |
dc.subject | Silver nanoparticle | en |
dc.title | Flow injection chemiluminescence determination of isoniazid using luminol and silver nanoparticles | en |
dc.type | Article (peer-reviewed) | en |
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