Flow injection chemiluminescence determination of isoniazid using luminol and silver nanoparticles

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dc.contributor.authorHaghighi, Behzad
dc.contributor.authorBozorgzadeh, Somayyeh
dc.contributor.funderInstitute for Advanced Studies in Basic Sciences (IASBS), Iranen
dc.date.accessioned2022-08-31T09:12:27Z
dc.date.available2022-08-31T09:12:27Z
dc.date.issued2010-12-01
dc.date.updated2022-08-31T09:09:06Z
dc.description.abstractThe effect of silver colloidal nanoparticles (AgNPs) on the luminol-isoniazid system was investigated. It was found that AgNPs could act as a nanocatalyst on the luminol-isoniazid system to generate chemiluminescence (CL). The CL emission spectrum of the luminol-isoniazid-AgNPs system showed a peak with a maximum at 425 nm. It was suggested that the luminophor species was the excited state 3-aminophthalate. The reduction of dissolved O2 to H2O2 by isoniazid and decomposition of H2O2 to the oxygen-related radicals were attributed to the catalytic effect of AgNPs. Under optimized conditions, the CL signal intensity was linear with the isoniazid concentration in the range of 10-1000 ng mL- 1, with the correlation coefficient of 0.9996. The limit of detection was 2.7 ng mL- 1 isoniazid. The relative standard deviations for seven repeated measurements of 60 and 200 ng mL- 1 isoniazid were 1.4 and 2.4%, respectively. The effect of potent interfering compounds on the CL signal intensity of the proposed luminol-isoniazid-AgNPs system was investigated. The proposed method was successfully applied to the determination of isoniazid in a pharmaceutical sample.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationHaghighi, B. and Bozorgzadeh, S. (2010) 'Flow injection chemiluminescence determination of isoniazid using luminol and silver nanoparticles', Microchemical Journal, 95 (2), pp. 192-197. doi: 10.1016/j.microc.2009.11.012en
dc.identifier.doi10.1016/j.microc.2009.11.012en
dc.identifier.endpage197en
dc.identifier.issn0026-265X
dc.identifier.issued2en
dc.identifier.journaltitleMicrochemical Journalen
dc.identifier.startpage192en
dc.identifier.urihttps://hdl.handle.net/10468/13519
dc.identifier.volume95en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urihttps://doi.org/10.1016/j.microc.2009.11.012
dc.rights© 2010 Elsevier B. V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectChemiluminescenceen
dc.subjectFlow injection analysisen
dc.subjectIsoniaziden
dc.subjectLuminolen
dc.subjectSilver nanoparticleen
dc.titleFlow injection chemiluminescence determination of isoniazid using luminol and silver nanoparticlesen
dc.typeArticle (peer-reviewed)en
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