Biophotonics diagnostics of oral cancer using Raman spectroscopy

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dc.contributor.authorMaryam, Siddraen
dc.contributor.authorGhauri, M. Daniyalen
dc.contributor.authorFahy, Edwarden
dc.contributor.authorSekar, Sanathana Konugolu Venkataen
dc.contributor.authorNogueira, Marcelo Saitoen
dc.contributor.authorLu, Huihuien
dc.contributor.authorRusso, Alidaen
dc.contributor.authorBurke, Rayen
dc.contributor.authorFeeley, Lindaen
dc.contributor.authorSheahan, Patricken
dc.contributor.authorNi Riordain, Richealen
dc.contributor.authorAndersson-Engels, Stefanen
dc.contributor.authorKho, Kiang Weien
dc.contributor.authorGautam, Rekhaen
dc.contributor.editorLilge, Lothar D.en
dc.contributor.editorHuang, Zhiweien
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2023-09-19T15:43:02Z
dc.date.available2023-09-19T15:43:02Z
dc.date.issued2023-08-11en
dc.description.abstractOral cancer (OC) is one of the most common oral malignancies. Despite significant advances in medical devices, the five-year survival rate of OC remains low. Current technologies based on tissue pathology are insufficient to diagnose OC at early stages. Molecular sensitive technique such as optical spectroscopy, on the other hand, has the potential for early-stage diagnostics and non-invasive tissue interrogation. Raman spectroscopy (RS), for instance, is a powerful vibrational spectroscopy that allows highly sensitive detection of low concentration analytes, as well as molecular fingerprints of bio samples to be studied non-invasively. Additionally, higher spatial resolution, narrow peaks, better sensitivity and minimal sample preparation makes RS a potential tool for analysing oral cancer in a clinical setting. In this study, we will validate the potential of Raman spectroscopy (RS) and surface enhanced Raman spectroscopy (SERS) for oral cancer diagnostics. Patients having biopsy and histopathological examination were involved in this study. Ex vivo measurements were performed on saliva specimen using SERS while in-vivo analysis was performed by RS. Integration of in vivo tissue and ex vivo sample analysis could potentially improve early-stage OC detection, and hence the overall survival rate of OC.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid126270Ben
dc.identifier.citationMaryam, S., Ghauri, M. D., Fahy, E., Sekar, S. K. V., Nogueira, M. S., Lu, H., Russo, A., Burke, R., Feelay, L., Sheahan, P., Ni Riordain, R., Andersson-Engels, S., Kho, K. W. and Gautam, R. (2023) 'Biophotonics diagnostics of oral cancer using Raman spectroscopy', Proceedings of SPIE, 12627, Translational Biophotonics: Diagnostics and Therapeutics III, 126270B (4pp). doi: 10.1117/12.2670600en
dc.identifier.doi10.1117/12.2670600en
dc.identifier.eissn1996-756Xen
dc.identifier.endpage4en
dc.identifier.issn0277-786Xen
dc.identifier.journaltitleProceedings of SPIEen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/15005
dc.identifier.volume12627en
dc.language.isoenen
dc.publisherSociety of Photo-Optical Instrumentation Engineers (SPIE)en
dc.relation.ispartofTranslational Biophotonics: Diagnostics and Therapeutics IIIen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Professorship Programme/15/RP/2828/IE/Novel applications and techniques for in vivo optical imaging and spectroscopy/en
dc.rights© 2023, SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this publication for a fee or for commercial purposes, and modification of the contents of the publication are prohibited.en
dc.subjectOral canceren
dc.subjectDetectionen
dc.subjectRaman spectroscopyen
dc.titleBiophotonics diagnostics of oral cancer using Raman spectroscopyen
dc.typeConference itemen
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