A retrospective biopharmaceutical analysis of >800 approved oral drug products: Are drug properties of solid dispersions and lipid-based formulations distinctive?

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dc.check.date2021-08-19
dc.check.infoAccess to this article is restricted until 12 months after publication by request of the publisher.en
dc.contributor.authorBennett-Lenane, Harriet
dc.contributor.authorO'Shea, Joseph P.
dc.contributor.authorO'Driscoll, Caitríona M.
dc.contributor.authorGriffin, Brendan T.
dc.contributor.funderIrish Research Councilen
dc.date.accessioned2020-09-10T07:31:49Z
dc.date.available2020-09-10T07:31:49Z
dc.date.issued2020-08-19
dc.date.updated2020-09-10T07:19:28Z
dc.description.abstractIncreasing numbers of poorly water soluble drugs in development has intensified need for bio-enabling formulations including Lipid-Based Formulations (LBF) and Solid Dispersions (SD). Resultantly, a data-driven approach is required to increase formulation development efficiency. This review provides a retrospective analysis of molecular and biopharmaceutical properties of drugs commercialised as LBFs or SDs. A comprehensive stepwise statistical analysis of LBF and SD drug properties was conducted and compared to drugs not commercialised via either technology (Others), aiming to identify key predictors of successful formulation development. This review demonstrates LBF and SD drugs differ significantly in molecular weight, polar surface area, rotatable bonds and hydrogen bond acceptor count. Meanwhile, LBF and SD drugs display significantly different aqueous solubility, lipophilicity, size, molecular flexibility, hydrogen bonding capacity and rule-of-5 violations versus Others. LBF and SDs were 3 and 5 times more likely to display >1 rule-of-5 violation versus Others, over 55% of LBF drugs exceeded the reported melting point guide of 10 Hydrogen Bond Acceptors. Overall, by focusing on successfully commercialised drugs, this review provides improved understanding of links between drug properties and successful SD/LBF approaches, providing a framework for guiding pharmaceutical development on formulation approaches.en
dc.description.sponsorshipIrish Research Council (Post Graduate Scholarship Project Number: GOIPG/2018/883)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationBennett-Lenane, H., O'Shea, J. P., O'Driscoll, C. M. and Griffin, B. T. (2020) 'A retrospective biopharmaceutical analysis of >800 approved oral drug products: Are drug properties of solid dispersions and lipid-based formulations distinctive?', Journal of Pharmaceutical Sciences. doi: 10.1016/j.xphs.2020.08.008en
dc.identifier.doi10.1016/j.xphs.2020.08.008en
dc.identifier.eissn1520-6017
dc.identifier.issn0022-3549
dc.identifier.journaltitleJournal of Pharmaceutical Sciencesen
dc.identifier.urihttps://hdl.handle.net/10468/10498
dc.language.isoenen
dc.publisherElsevier Inc.en
dc.rights© 2020, American Pharmacists Association®. Published by Elsevier Inc. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectSolid dispersion(s)en
dc.subjectLipid-based formulation(s)en
dc.subjectPoorly water-soluble drug(s)en
dc.subjectFormulationen
dc.subjectDrug-like property(s)en
dc.subjectAmorphous solid dispersion(s) (ASD)en
dc.subjectBioavailabilityen
dc.subjectDrug delivery systemsen
dc.titleA retrospective biopharmaceutical analysis of >800 approved oral drug products: Are drug properties of solid dispersions and lipid-based formulations distinctive?en
dc.typeArticle (peer-reviewed)en
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