Preeclampsia and cardiovascular disease in a large UK pregnancy cohort of linked electronic health records: a CALIBER study

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dc.check.date2020-03-23
dc.check.infoAccess to this article is restricted until 6 months after publication by request of the publisher.en
dc.contributor.authorLeon, Lydia J.
dc.contributor.authorMcCarthy, Fergus P.
dc.contributor.authorDirek, Kenan
dc.contributor.authorGonzalez-Izquierdo, Arturo
dc.contributor.authorPrieto-Merino, David
dc.contributor.authorCasas, Juan P.
dc.contributor.authorChappell, Lucy
dc.contributor.funderNational Institute for Health Researchen
dc.contributor.funderUCLH Biomedical Research Centreen
dc.date.accessioned2019-10-17T13:12:13Z
dc.date.available2019-10-17T13:12:13Z
dc.date.issued2019-09-23
dc.description.abstractBackground: The associations between pregnancy hypertensive disorders and common cardiovascular disorders have not been investigated at scale in a contemporaneous population. We aimed to investigate the association between preeclampsia, hypertensive disorders of pregnancy, and subsequent diagnosis of 12 different cardiovascular disorders. Methods: We used linked electronic health records from 1997 to 2016 to recreate a UK population-based cohort of 1.3 million women, mean age at delivery 28 years, with nearly 1.9 million completed pregnancies. We used multivariable Cox models to determine the associations between hypertensive disorders of pregnancy, and preeclampsia alone (term and preterm), with 12 cardiovascular disorders in addition to chronic hypertension. We estimated the cumulative incidence of a composite end point of any cardiovascular disorder according to preeclampsia exposure. Results: During the 20-year study period, 18 624 incident cardiovascular disorders were observed, 65% of which had occurred in women under 40 years. Compared to women without hypertension in pregnancy, women who had 1 or more pregnancies affected by preeclampsia had a hazard ratio of 1.9 (95% confidence interval 1.53–2.35) for any stroke, 1.67 (1.54–1.81) for cardiac atherosclerotic events, 1.82 (1.34–2.46) for peripheral events, 2.13 (1.64–2.76) for heart failure, 1.73 (1.38–2.16) for atrial fibrillation, 2.12 (1.49–2.99) for cardiovascular deaths, and 4.47 (4.32–4.62) for chronic hypertension. Differences in cumulative incidence curves, according to preeclampsia status, were apparent within 1 year of the first index pregnancy. Similar patterns of association were observed for hypertensive disorders of pregnancy, while preterm preeclampsia conferred slightly further elevated risks. Conclusions: Hypertensive disorders of pregnancy, including preeclampsia, have a similar pattern of increased risk across all 12 cardiovascular disorders and chronic hypertension, and the impact was evident soon after pregnancy. Hypertensive disorders of pregnancy should be considered as a natural screening tool for cardiovascular events, enabling cardiovascular risk prevention through national initiatives.en
dc.description.sponsorshipNational Institute for Health Research (Professorship (RP-2014-05-019); Clinical Academic Fellowship; University College London Hospitals Biomedical Research Centre)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationLeon, L. J., McCarthy, F. P., Direk, K., Gonzalez-Izquierdo, A., Prieto-Merino, D., Casas, J. P. and Chappell, L. (2019) 'Preeclampsia and Cardiovascular Disease in a Large UK Pregnancy Cohort of Linked Electronic Health Records', Circulation, 140(13), pp. 1050-1060. doi: 10.1161/CIRCULATIONAHA.118.038080en
dc.identifier.doi10.1161/CIRCULATIONAHA.118.038080en
dc.identifier.eissn1524-4539
dc.identifier.endpage1060en
dc.identifier.issn0009-7322
dc.identifier.issued13en
dc.identifier.journaltitleCirculationen
dc.identifier.startpage1050en
dc.identifier.urihttps://hdl.handle.net/10468/8793
dc.identifier.volume140en
dc.language.isoenen
dc.publisherLippincott, Williams & Wilkins; American Heart Associationen
dc.rights© 2019 American Heart Association, Inc. Published by Lippincott, Williams & Wilkins.en
dc.subjectCardiovascular diseasesen
dc.subjectHypertensionen
dc.subjectHypertension, pregnancy-induceden
dc.subjectPreeclampsiaen
dc.subjectPregnancyen
dc.titlePreeclampsia and cardiovascular disease in a large UK pregnancy cohort of linked electronic health records: a CALIBER studyen
dc.typeArticle (peer-reviewed)en
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