Electroencephalographic sleep macrostructure and sleep spindles in early infancy

dc.contributor.authorVentura, Soraia
dc.contributor.authorMathieson, Sean R.
dc.contributor.authorO'Toole, John M.
dc.contributor.authorLivingstone, Vicki
dc.contributor.authorRyan, Mary Anne
dc.contributor.authorBoylan, Geraldine B.
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderJohnson and Johnsonen
dc.date.accessioned2021-11-30T16:03:18Z
dc.date.available2021-11-30T16:03:18Z
dc.date.issued2021-11-10
dc.date.updated2021-11-30T15:48:13Z
dc.description.abstractStudy Objectives: Sleep features in infancy are potential biomarkers for brain maturation but poorly characterized. We describe normative values for sleep macrostructure and sleep spindles at 4–5 months of age. Methods: Healthy term infants were recruited at birth and had daytime sleep electroencephalograms (EEGs) at 4–5 months. Sleep staging was performed and five features were analyzed. Sleep spindles were annotated and seven quantitative features were extracted. Features were analyzed across sex, recording time (am/pm), infant age, and from first to second sleep cycles. Results: We analyzed sleep recordings from 91 infants, 41% females. Median (interquartile range [IQR]) macrostructure results: sleep duration 49.0 (37.8–72.0) min (n = 77); first sleep cycle duration 42.8 (37.0–51.4) min; rapid eye movement (REM) percentage 17.4 (9.5–27.7)% (n = 68); latency to REM 36.0 (30.5–41.1) min (n = 66). First cycle median (IQR) values for spindle features: number 241.0 (193.0–286.5), density 6.6 (5.7–8.0) spindles/min (n = 77); mean frequency 13.0 (12.8–13.3) Hz, mean duration 2.9 (2.6–3.6) s, spectral power 7.8 (4.7–11.4) µV2, brain symmetry index 0.20 (0.16–0.29), synchrony 59.5 (53.2–63.8)% (n = 91). In males, spindle spectral power (µV2) was 24.5% lower (p = .032) and brain symmetry index 24.2% higher than females (p = .011) when controlling for gestational and postnatal age and timing of the nap. We found no other significant associations between studied sleep features and sex, recording time (am/pm), or age. Spectral power decreased (p < .001) on the second cycle. Conclusion: This normative data may be useful for comparison with future studies of sleep dysfunction and atypical neurodevelopment in infancy. Clinical Trial Registration: BABY SMART (Study of Massage Therapy, Sleep And neurodevelopMenT) (BabySMART). URL: https://clinicaltrials.gov/ct2/show/results/NCT03381027?view=results. ClinicalTrials.gov Identifier: NCT03381027en
dc.description.sponsorshipScience Foundation Ireland (SFI under Grant Number 15/SIRG/3580)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleidzsab262en
dc.identifier.citationVentura, S., Mathieson, S. R., O'Toole, J. M., Livingstone, V., Ryan, M.-A. and Boylan, G. B. (2021) 'Electroencephalographic sleep macrostructure and sleep spindles in early infancy', Sleep, zsab262 (15 pp). doi: 10.1093/sleep/zsab262en
dc.identifier.doi10.1093/sleep/zsab262en
dc.identifier.endpage15en
dc.identifier.issn0161-8105
dc.identifier.journaltitleSleepen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/12291
dc.language.isoenen
dc.publisherOxford University Pressen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2272/IE/Irish Centre for Fetal and Neonatal Translational Research (INFANT)/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Spokes Programme/15/SP/3091/IE/ENRICH: Baby Enrichment Research Programme/en
dc.rights© Sleep Research Society 2021. Published by Oxford University Press on behalf of the Sleep Research Society. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectNeurodevelopmenten
dc.subjectSleepen
dc.subjectSpindlesen
dc.subjectMacrostructureen
dc.subjectInfanten
dc.subjectEEGen
dc.subjectREMen
dc.subjectNREMen
dc.subjectNapen
dc.titleElectroencephalographic sleep macrostructure and sleep spindles in early infancyen
dc.typeArticle (peer-reviewed)en
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