The gut microbiota in anxiety and depression - A systematic review

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dc.contributor.authorSimpson, Carra A.
dc.contributor.authorDiaz-Arteche, Carmela
dc.contributor.authorEliby, Djamila
dc.contributor.authorSchwartz, Orli S.
dc.contributor.authorSimmons, Julian G.
dc.contributor.authorCowan, Caitlin S. M.
dc.contributor.funderAustralian Government Research Training Programen
dc.date.accessioned2021-01-14T09:48:23Z
dc.date.available2021-01-14T09:48:23Z
dc.date.issued2020-10-29
dc.date.updated2021-01-14T09:34:45Z
dc.description.abstractGrowing evidence indicates the community of microorganisms throughout the gastrointestinal tract, (i.e., gut microbiota), is associated with anxiety and depressive disorders. We present the first systematic review of the gut microbiota in anxiety disorders, along with an update in depression. Consideration of shared underlying features is essential due to the high rates of comorbidity. Systematic searches, following PRISMA guidelines, identified 26 studies (two case-control comparisons of the gut microbiota in generalised anxiety disorder, 18 in depression, one incorporating both anxiety/depression, and five including symptom-only measures). Alpha and beta diversity findings were inconsistent; however, differences in bacterial taxa indicated disorders may be characterised by a higher abundance of proinflammatory species (e.g., Enterobacteriaceae and Desulfovibrio), and lower short-chain fatty acid producing-bacteria (e.g., Faecalibacterium). Several taxa, and their mechanisms of action, may relate to anxiety and depression pathophysiology via communication of peripheral inflammation to the brain. Although the gut microbiota remains a promising target for prevention and therapy, future research should assess confounders, particularly diet and psychotropic medications, and should examine microorganism function.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid101943en
dc.identifier.citationSimpson, C. A., Diaz-Arteche, C., Eliby, D., Schwartz, O. S., Simmons, J. G. and Cowan, C. S. M. (2020) 'The gut microbiota in anxiety and depression - A systematic review', Clinical Psychology Review, 83, 101943 (18pp). doi: 10.1016/j.cpr.2020.101943en
dc.identifier.doi10.1016/j.cpr.2020.101943en
dc.identifier.endpage18en
dc.identifier.issn1873-7811
dc.identifier.issn0272-7358
dc.identifier.journaltitleClinical Psychology Reviewen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/10910
dc.identifier.volume83en
dc.language.isoenen
dc.publisherElsevier Ltd.en
dc.rights© 2020, Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectAnxiety disordersen
dc.subjectDepressionen
dc.subjectMicrobiomeen
dc.subjectGut-brain axisen
dc.subjectMicrobiotaen
dc.titleThe gut microbiota in anxiety and depression - A systematic reviewen
dc.typeArticle (peer-reviewed)en
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