The relationship between fish intake and urinary trimethylamine-N-oxide.

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dc.contributor.authorYin, Xiaofei
dc.contributor.authorGibbons, Helena
dc.contributor.authorRundle, Milena
dc.contributor.authorFrost, Gary
dc.contributor.authorMcNulty, Breige A.
dc.contributor.authorNugent, Anne P.
dc.contributor.authorWalton, Janette
dc.contributor.authorFlynn, Albert
dc.contributor.authorBrennan, Lorraine
dc.contributor.funderSeventh Framework Programmeen
dc.contributor.funderEuropean Research Councilen
dc.contributor.funderHorizon 2020en
dc.contributor.funderDepartment of Agriculture, Food and the Marineen
dc.date.accessioned2020-02-27T16:03:09Z
dc.date.available2020-02-27T16:03:09Z
dc.date.issued2019-12-21
dc.date.updated2020-02-27T15:52:04Z
dc.description.abstractScope: Fish intake is reported to be associated with certain health benefits; however, accurate assessment of fish intake is still problematic. The objective of this study is to identify fish intake biomarkers and examine relationships with health parameters in a free‐living population. Methods and results: In the NutriTech study, ten participants randomized into the fish group consume increasing quantities of fish for 3 days per week for 3 weeks. Urine is analyzed by NMR spectroscopy. Trimethylamine‐N‐oxide (TMAO), dimethylamine, and dimethyl sulfone are identified and display significant dose–response with intake (p < 0.05). Fish consumption yields a greater increase in urinary TMAO compared to red meat. Biomarker‐derived fish intake is calculated in the National Adult Nutrition Survey cross‐sectional study. However, the correlation between fish intake and TMAO (r = 0.148, p < 0.01) and that between fish intake and calculated fish intake (r = 0.142, p < 0.01) are poor. In addition, TMAO shows significantly positive correlation with serum insulin and insulin resistance in males and the relationship is more pronounced for males with high dietary fat intake. Conclusion: Urinary TMAO displays a strong dose–response relationship with fish intake; however, use of TMAO alone is insufficient to determine fish intake in a free‐living population.en
dc.description.sponsorshipDepartment of Agriculture, Fisheries, and Food, Ireland (under the Food for Health Research Initiative (2007–2012; 7FHRIUCC2)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid1900799en
dc.identifier.citationYin, X., Gibbons, H., Rundle, M., Frost, G., McNulty, B. A., Nugent, A. P., Walton, J., Flynn, A. and Brennan, L. (2020) 'The Relationship between Fish Intake and Urinary Trimethylamine-N-Oxide', Molecular Nutrition & Food Research, 64(3), 1900799 (9 pp). doi: 10.1002/mnfr.201900799en
dc.identifier.doi10.1002/mnfr.201900799en
dc.identifier.endpage9en
dc.identifier.issn1613-4125
dc.identifier.issued3en
dc.identifier.journaltitleMolecular Nutrition & Food Researchen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/9710
dc.identifier.volume64en
dc.language.isoenen
dc.publisherWileyen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/289511/EU/Application of new technologies and methods in nutrition research – the example of phenotypic flexibility/NUTRITECHen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::ERC::ERC-COG/647783/EU/Metabolomics based biomarkers of dietary intake- new tools for nutrition research/A-DIETen
dc.relation.urihttps://onlinelibrary.wiley.com/doi/full/10.1002/mnfr.201900799
dc.rights© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the following article: ‘The Relationship between Fish Intake and Urinary Trimethylamine‐N‐Oxide’, Mol. Nutr. Food Res. 2020, 64, 1900799.which has been published in final form at https://doi.org/10.1002/mnfr.201900799. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.en
dc.subjectDietary biomarkersen
dc.subjectFish intakeen
dc.subjectMetabolomicsen
dc.subjecttrimethylamine‐N‐oxideen
dc.titleThe relationship between fish intake and urinary trimethylamine-N-oxide.en
dc.typeArticle (peer-reviewed)en
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