What can the gut microbiome teach us about the connections between child physical and mental health? A systematic review

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dc.contributor.authorKan, Janice M.
dc.contributor.authorCowan, Caitlin S. M.
dc.contributor.authorOoi, Chee Y.
dc.contributor.authorKasparian, Nadine A.
dc.contributor.funderNational Heart Foundation of Australiaen
dc.contributor.funderNational Health and Medical Research Councilen
dc.contributor.funderCommonwealth Funden
dc.contributor.funderHorizon 2020en
dc.contributor.funderUniversity of New South Walesen
dc.contributor.funderSydney Partnership for Health, Education, Research and Enterprise
dc.date.accessioned2019-02-01T11:23:18Z
dc.date.available2019-02-01T11:23:18Z
dc.date.issued2019-01-08
dc.date.updated2019-02-01T10:10:14Z
dc.description.abstractA deeper understanding of the gut-brain axis is of significance in pediatrics, given the influential role of early childhood experiences and exposures in shaping the microbiome, and health, across the life course. This systematic review synthesized evidence on the connection between the gut microbiome and mental health in children with physical illness. Six electronic databases were systematically searched and data extracted according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Of 1,476 identified articles, 11 articles reporting on nine unique studies (all randomized controlled trials) were included. Most studies examined the gut microbiome in infants with colic, while the remaining studies investigated outcomes in children aged 1 day to 18 years at risk for atopic dermatitis or irritable bowel syndrome. Baseline and postintervention gut microbiome differences varied across studies. Findings on psychological functioning also varied, with only half of the captured studies showing a positive effect of intervention on psychological well-being. Only two studies analyzed the association between the gut microbiome and psychological outcomes, each with a different pattern of results. As the field moves forward, it will be critical to gain a better understanding of the microbiome characteristics that influence mental health outcomes in pediatric populations.en
dc.description.sponsorshipNational Heart Foundation of Australia (Future Leader Fellowship - Grant Number: 101229); National Health and Medical Research Council (Grant Number: APP1081001); Commonwealth Fund (Harkness Fellowship in Health Care Policy & Practice); University of New South Wales and Sydney Partnership for Health, Education, Research and Enterprise (2017 Seed Funding)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationKan, J. M., Cowan, C. S. M., Ooi, C. Y. and Kasparian, N. A. (2019) 'What can the gut microbiome teach us about the connections between child physical and mental health? A systematic review', Developmental Psychobiology, pp. 1-14. doi:10.1002/dev.21819en
dc.identifier.doi10.1002/dev.21819
dc.identifier.endpage14en
dc.identifier.issn0012-1630
dc.identifier.issn1098-2302
dc.identifier.journaltitleDevelopmental Psychobiologyen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/7420
dc.language.isoenen
dc.publisherJohn Wiley & Sons, Inc.en
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::MSCA-IF-EF-ST/797592/EU/Gut microbiota-Microglia Interactions in NeuroDevelopment/GutMINDen
dc.rights© 2019, Wiley Periodicals, Inc. This is the peer reviewed version of the following article: Kan, J. M., Cowan, C. S. M., Ooi, C. Y. and Kasparian, N. A. (2019) 'What can the gut microbiome teach us about the connections between child physical and mental health? A systematic review', Developmental Psychobiology, pp. 1-14. doi:10.1002/dev.21819, which has been published in final form at https://doi.org/10.1002/dev.21819. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en
dc.subjectChildhooden
dc.subjectChronic illnessen
dc.subjectMental healthen
dc.subjectMicrobiomeen
dc.subjectPhysical healthen
dc.subjectQuality of lifeen
dc.titleWhat can the gut microbiome teach us about the connections between child physical and mental health? A systematic reviewen
dc.typeArticle (peer-reviewed)en
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