Merkel-cell carcinoma: local recurrence rate versus radiation dose study from a 949-patient database
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Published Version
Date
2025
Authors
Tai, Patricia
Veness, Michael
Prajapati, Vimal H.
Jones Thachuthara, Aoife
Lian, Jidong
Assouline, Avi
Yu, Edward
Joseph, Kurian
Journal Title
Journal ISSN
Volume Title
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Published Version
Abstract
(1) Background: Knowledge regarding the optimal radiotherapy dose for Merkel-cell carcinoma (MCC) remains limited. (2) Methods: Following a PubMed search, equivalent doses in 2 Gy fractions (Gy2) were compared. (3) Results: Of the 949 patients, 939 were evaluable, with 728 (77.5%) cases localized to the primary site and 171 irradiated without chemotherapy. The overall local recurrence rate (LRR) was 23% (40/171). After definitive radiotherapy with EQD2 < 50 Gy2 versus ≥50 Gy2, the LRRs were 23.1% (3/13) and 12.5% a(1/8), respectively (p = 0.0004). (4) Conclusions: For definitive radiotherapy, EQD2 < 50 Gy2 demonstrates a significantly higher LRR than ≥50 Gy2 (p = 0.0004). This study is clinically useful and unique with stratification by definitive/adjuvant settings and positive/negative resection margins. A future prospective multicenter study is needed to determine the optimal radiotherapy doses.
Description
Keywords
Database , Local recurrence , Merkel-cell carcinoma , Pattern of spread , Radiotherapy dose , Skin
Citation
Tai, P., Veness, M., Prajapati, V. H., Jones Thachuthara, A., Lian, J., Assouline, A., Yu, E. and Joseph, K. (2025) 'Merkel-cell carcinoma: local recurrence rate versus radiation dose study from a 949-patient database', Current Oncology, 32(4), 202 (10pp). https://doi.org/10.3390/curroncol32040202