Merkel-cell carcinoma: local recurrence rate versus radiation dose study from a 949-patient database

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dc.contributor.authorTai, Patriciaen
dc.contributor.authorVeness, Michaelen
dc.contributor.authorPrajapati, Vimal H.en
dc.contributor.authorJones Thachuthara, Aoifeen
dc.contributor.authorLian, Jidongen
dc.contributor.authorAssouline, Avien
dc.contributor.authorYu, Edwarden
dc.contributor.authorJoseph, Kurianen
dc.date.accessioned2025-05-13T08:54:25Z
dc.date.available2025-05-13T08:54:25Z
dc.date.issued2025en
dc.description.abstract(1) Background: Knowledge regarding the optimal radiotherapy dose for Merkel-cell carcinoma (MCC) remains limited. (2) Methods: Following a PubMed search, equivalent doses in 2 Gy fractions (Gy2) were compared. (3) Results: Of the 949 patients, 939 were evaluable, with 728 (77.5%) cases localized to the primary site and 171 irradiated without chemotherapy. The overall local recurrence rate (LRR) was 23% (40/171). After definitive radiotherapy with EQD2 < 50 Gy2 versus ≥50 Gy2, the LRRs were 23.1% (3/13) and 12.5% a(1/8), respectively (p = 0.0004). (4) Conclusions: For definitive radiotherapy, EQD2 < 50 Gy2 demonstrates a significantly higher LRR than ≥50 Gy2 (p = 0.0004). This study is clinically useful and unique with stratification by definitive/adjuvant settings and positive/negative resection margins. A future prospective multicenter study is needed to determine the optimal radiotherapy doses.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid202en
dc.identifier.citationTai, P., Veness, M., Prajapati, V. H., Jones Thachuthara, A., Lian, J., Assouline, A., Yu, E. and Joseph, K. (2025) 'Merkel-cell carcinoma: local recurrence rate versus radiation dose study from a 949-patient database', Current Oncology, 32(4), 202 (10pp). https://doi.org/10.3390/curroncol32040202en
dc.identifier.doi10.3390/curroncol32040202en
dc.identifier.issn17187729en
dc.identifier.issued4
dc.identifier.journaltitleCurrent Oncologyen
dc.identifier.urihttps://hdl.handle.net/10468/17451
dc.identifier.volume32
dc.language.isoenen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)en
dc.rights© 2025, the Author(s). Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectDatabaseen
dc.subjectLocal recurrenceen
dc.subjectMerkel-cell carcinomaen
dc.subjectPattern of spreaden
dc.subjectRadiotherapy doseen
dc.subjectSkinen
dc.subject~Medicine - Journal Articles~en
dc.titleMerkel-cell carcinoma: local recurrence rate versus radiation dose study from a 949-patient databaseen
dc.typeArticle (peer reviewed)en
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